The NM-INBRE DRPP provides critical support for promising new and early career investigators, and is a determining factor in the direction of their developing research careers. These projects address significant biomedical questions and critical health problems in the areas of Brain and Behavioral Health; Cancer; Cardiovascular and Metabolic Diseases; Child Health; Environmental Health; Infectious Disease and Immunity. The quality of the DRPP science is outstanding, resulting in publications in high impact journals, and pending patents for novel pancratistatin and rigidin analogues with anticancer properties. Efforts to encourage research collaboration have been successful, during the current funding period 23% of the publications have involved collaborations between 2 or more NM-INBRE participants, and this trend is expected to increase in the continuing program. Investigators have been successful in competing for external federal grants, in spite of the difficult funding environment, including recent R01, R21, R03, and R15 awards. The DRPP has made significant impacts on the partner institutions, such as San Juan College, a two-year associate degree-granting institution in the four-corners region with a large Native American student population, where the research activity supported by the NM-INBRE was leveraged to justify a competitive application for an NSF grant to remodel the research space and install a clean room that was funded and now supports research projects. The framework of DRPP projects also serve the primary objective of exposing students to research experiences, and this impact will continue with increased opportunities through an expanded portfolio of projects.

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM103451-16
Application #
9038382
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2016-04-01
Budget End
2017-03-31
Support Year
16
Fiscal Year
2016
Total Cost
Indirect Cost
Name
New Mexico State University Las Cruces
Department
Type
DUNS #
173851965
City
Las Cruces
State
NM
Country
United States
Zip Code
88003
Niroula, Doleshwar; Hallada, Liam P; Le Chapelain, Camille et al. (2018) Design, synthesis, and evaluation of cystargolide-based ?-lactones as potent proteasome inhibitors. Eur J Med Chem 157:962-977
Yan, Hao; Bhattarai, Umesh; Song, Yabin et al. (2018) Design, synthesis and activity of light deactivatable microRNA inhibitor. Bioorg Chem 80:492-497
Zhong, Hua; Song, Mingzhou (2018) A fast exact functional test for directional association and cancer biology applications. IEEE/ACM Trans Comput Biol Bioinform :
Nemunaitis, Jacklyn M; Brown-Glabeman, Ursa; Soares, Heloisa et al. (2018) Gallbladder cancer: review of a rare orphan gastrointestinal cancer with a focus on populations of New Mexico. BMC Cancer 18:665
Sheng, Haiqing; Duan, Mingrui; Hunter, Samuel S et al. (2018) High-Quality Complete Genome Sequences of Three Bovine Shiga Toxin-ProducingEscherichia coliO177:H- (fliCH25) Isolates Harboring Virulentstx2and Multiple Plasmids. Genome Announc 6:
Dominguez, Matthew J; Lantz, Benjamin J; Rhode, Rebecca J et al. (2018) A multi-column plate adapter provides an economical and versatile high-throughput protein purification system. Protein Expr Purif 152:84-91
DeVore, Stanley B; Young, Coleman H; Li, Guangyuan et al. (2018) Histone citrullination represses miRNA expression resulting in increased oncogene mRNAs in somatolactotrope cells. Mol Cell Biol :
Licon-Munoz, Yamhilette; Fordyce, Colleen A; Hayek, Summer Raines et al. (2018) V-ATPase-dependent repression of androgen receptor in prostate cancer cells. Oncotarget 9:28921-28934
Gautam, Gayatri P; Gurung, Rubi; Fencl, Frank A et al. (2018) Separation of sub-micron particles from micron particles using acoustic fluid relocation combined with acoustophoresis. Anal Bioanal Chem 410:6561-6571
Brown, Tom; Brown, Nick; Stollar, Elliott J (2018) Most yeast SH3 domains bind peptide targets with high intrinsic specificity. PLoS One 13:e0193128

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