Abstract

Analytical Core The Analytical Chemistry Core Facility will consist of instrumentation and infrastructure for molecular characterization through use of Mass Spectrometry (MS), Nuclear Magnetic Resonance (NMR) spectroscopy, and a suite of instruments that compose our Kinetics Laboratory. The instrumentation in the core was used extensively by Phase I investigators, and these instruments will continue to be used in Phase II by researchers across the IDeA network and beyond. The goals of the Analytical Chemistry Core are (1) development of an administrative framework for the Analytical Chemistry Core Facility, (2) development of the COBRE-supported Mass Spectrometry Laboratory, (3) development of the COBRE-supported Solution NMR Laboratory, and (4) development of the Kinetics Laboratory for monitoring chemical and biological reactions and for measuring molecular and biomolecular interactions. A plan is described for management, user training and sustainable support for the broad range of instrumentation throughout the core facility.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
2P20GM104316-06A1
Application #
10026270
Study Section
Special Emphasis Panel (ZGM1)
Project Start
2014-09-01
Project End
2025-06-30
Budget Start
2020-07-01
Budget End
2021-06-30
Support Year
6
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
University of Delaware
Department
Type
DUNS #
059007500
City
Newark
State
DE
Country
United States
Zip Code
19716

  Publications

Liang, Hai; Zhou, Guangfeng; Ge, Yunhui et al. (2018) Elucidating the inhibition of peptidoglycan biosynthesis in Staphylococcus aureus by albocycline, a macrolactone isolated from Streptomyces maizeus. Bioorg Med Chem 26:3453-3460
Wu, Pengcheng; Yap, Glenn P A; Theopold, Klaus H (2018) Structure and Reactivity of Chromium(VI) Alkylidenes. J Am Chem Soc 140:7088-7091
O'Brien, Jessica G K; Chintala, Srinivasa R; Fox, Joseph M (2018) Stereoselective Synthesis of Bicyclo[6.1.0]nonene Precursors of the Bioorthogonal Reagents s-TCO and BCN. J Org Chem 83:7500-7503
Guan, Weiye; Liao, Jennie; Watson, Mary P (2018) Vinylation of Benzylic Amines via C-N Bond Functionalization of Benzylic Pyridinium Salts. Synthesis (Stuttg) 50:3231-3237
Allgood, Samual C; Neunuebel, M Ramona (2018) The recycling endosome and bacterial pathogens. Cell Microbiol 20:e12857
Fang, Yinzhi; Zhang, Han; Huang, Zhen et al. (2018) Photochemical syntheses, transformations, and bioorthogonal chemistry of trans-cycloheptene and sila trans-cycloheptene Ag(i) complexes. Chem Sci 9:1953-1963
Rowland, Casey A; Lorzing, Gregory R; Gosselin, Eric J et al. (2018) Methane Storage in Paddlewheel-Based Porous Coordination Cages. J Am Chem Soc 140:11153-11157
Lyman, Edward; Hsieh, Chia-Lung; Eggeling, Christian (2018) From Dynamics to Membrane Organization: Experimental Breakthroughs Occasion a ""Modeling Manifesto"". Biophys J 115:595-604
Zhang, Zhengqi; Liu, Jun; Rozovsky, Sharon (2018) Preparation of Selenocysteine-Containing Forms of Human SELENOK and SELENOS. Methods Mol Biol 1661:241-263
DeMeester, Kristen E; Liang, Hai; Jensen, Matthew R et al. (2018) Synthesis of Functionalized N-Acetyl Muramic Acids To Probe Bacterial Cell Wall Recycling and Biosynthesis. J Am Chem Soc 140:9458-9465

Showing the most recent 10 out of 93 publications