Clemson University's foundation in eukaryotic pathogens research has led to the formation of the Eukaryotic Pathogens Innovation Center (EPIC), formally approved by the University Board of Trustees in January 2013, in order to strengthen this important area of biomedical research. The rationale for forming this Center was to provide recognition and enhance the strength of eukaryotic pathogen research at Clemson by promoting interactions among faculty.
The Specific Aims of the Administrative Core of this proposal are: (1) to strengthen the CU Eukaryotic Pathogens Innovation Center (EPIC), (2) to train target investigators to successfully compete for R01 funding, and (3) to assess the effectiveness of the organization of EPIC and training of target investigators. The Administrative Core provides funds for two pilot projects in eukaryotic pathogen research to recruit new members to EPIC. Funds are also provided for upgrades and enhancements to two core facilities, the Clemson Light Imaging Facility and the Clemson University Genomics Institute to provide services for EPIC and the university research community. Prominent scientists with related research interests and an extensive history of NIH funding will serve as mentor for the target investigators. These mentors, who have been handpicked by each target investigator in consultation with the PI and Co-PI, will provide scientific expertise and facilitate establishment of collaborations by the target investigators. They will also provide guidance and feedback in lab management, manuscript publication, and grant writing. Finally, an External Advisory Committee will assess the program and provide guidance in all aspects of this COBRE. Clemson University, the College of Agriculture, Forestry, and Life Sciences, and the Public Services Activities Administration have pledged substantial support for EPIC and this COBRE in terms of faculty hires (with competitive salary and start-up), graduate assistantships, and infrastructural renovations. The funds from this COBRE and the support from the University will bolster and strengthen EPIC into a nationally renowned center devoted to the research of eukaryotic pathogens.

Public Health Relevance

Eukaryotic pathogens are the causative agents of some of the most destructive and intractable diseases of man. The global impact of these diseases is immense, but these microbes also have local impact in South Carolina. The overarching theme of EPIC is the study of these eukaryotic pathogens using state-of-the art molecular, cellular, biochemical, genetic, and genomics approaches..

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM109094-02
Application #
9261572
Study Section
Special Emphasis Panel (ZGM1)
Project Start
Project End
Budget Start
2017-04-01
Budget End
2018-03-31
Support Year
2
Fiscal Year
2017
Total Cost
Indirect Cost
Name
Clemson University
Department
Type
DUNS #
042629816
City
Clemson
State
SC
Country
United States
Zip Code
29634
Tajielyato, Nayere; Li, Lin; Peng, Yunhui et al. (2018) E-hooks provide guidance and a soft landing for the microtubule binding domain of dynein. Sci Rep 8:13266
Kafková, Lucie; Tu, Chengjian; Pazzo, Kyle L et al. (2018) Trypanosoma brucei PRMT1 Is a Nucleic Acid Binding Protein with a Role in Energy Metabolism and the Starvation Stress Response. MBio 9:
Ramos-Garcia, Angel A; Shankar, Vijay; Saski, Christopher A et al. (2018) Draft Genome Sequence of the 1,4-Dioxane-Degrading Bacterium Pseudonocardia dioxanivorans BERK-1. Genome Announc 6:
Qiu, Yijian; Milanes, Jillian E; Jones, Jessica A et al. (2018) Glucose Signaling Is Important for Nutrient Adaptation during Differentiation of Pleomorphic African Trypanosomes. mSphere 3:
Ray, Sunayan S; Wilkinson, Christina L; Paul, Kimberly S (2018) Regulation of Trypanosoma brucei Acetyl Coenzyme A Carboxylase by Environmental Lipids. mSphere 3:
Altamirano, Sophie; Simmons, Charles; Kozubowski, Lukasz (2018) Colony and Single Cell Level Analysis of the Heterogeneous Response of Cryptococcus neoformans to Fluconazole. Front Cell Infect Microbiol 8:203
Gordhan, Heeren M; Milanes, Jillian E; Qiu, Yijian et al. (2017) A targeted delivery strategy for the development of potent trypanocides. Chem Commun (Camb) 53:8735-8738
Di Cristina, Manlio; Dou, Zhicheng; Lunghi, Matteo et al. (2017) Toxoplasma depends on lysosomal consumption of autophagosomes for persistent infection. Nat Microbiol 2:17096
Lin, Sheng; Voyton, Charles; Morris, Meredith T et al. (2017) pH regulation in glycosomes of procyclic form Trypanosoma brucei. J Biol Chem 292:7795-7805
Flaherty, Daniel P; Harris, Michael T; Schroeder, Chad E et al. (2017) Optimization and Evaluation of Antiparasitic Benzamidobenzoic Acids as Inhibitors of Kinetoplastid Hexokinase?1. ChemMedChem 12:1994-2005

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