Abstract

MM is a presently difficult-to-cure plasma cell malignancy that accumulates in the bone marrow (BM) and is clinically preceded by the asymptomatic plasma cell dyscrasias (PCD) known as monoclonal gammopathy of undetermined significance (MGUS), smoldering MM (SMM), which are distinguished from MM based on the lack of end-organ damage. MGUS occurs in 3% of the general population over the age of 50 and is typically detected. Individual with MGUS do not have any signs or symptoms. However, the risk of MGUS progressing to MM increases by ~1% each year. SMM is an intermediate stage between MGUS and MM with a higher risk of progression to MM, especially during the first five years. The clinical symptoms of MM include calcium dysregulation, renal dysfunction, anemia, and bone lesions (CRAB).

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of General Medical Sciences (NIGMS)
Type
Exploratory Grants (P20)
Project #
5P20GM125503-04
Application #
10332600
Study Section
Special Emphasis Panel (ZGM1)
Program Officer
Zhou, Yang
Project Start
2021-02-01
Project End
2023-01-31
Budget Start
2021-02-01
Budget End
2022-01-31
Support Year
4
Fiscal Year
2021
Total Cost
Indirect Cost

  Institution

Name
University of Arkansas for Medical Sciences
Department
Type
DUNS #
122452563
City
Little Rock
State
AR
Country
United States
Zip Code
72205

  Publications

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O'Brien, Charles A; Morello, Roy (2018) Modeling Rare Bone Diseases in Animals. Curr Osteoporos Rep 16:458-465
Ambrogini, Elena; Que, Xuchu; Wang, Shuling et al. (2018) Oxidation-specific epitopes restrain bone formation. Nat Commun 9:2193
Went, Molly; Sud, Amit; Försti, Asta et al. (2018) Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. Nat Commun 9:3707
Piccolo, Brian D; Graham, James L; Stanhope, Kimber L et al. (2018) Diabetes-Associated Alterations in the Cecal Microbiome and Metabolome are Independent of Diet or Environment in the UC Davis Type 2-Diabetes Mellitus Rat Model. Am J Physiol Endocrinol Metab :
Rasche, Leo; Angtuaco, Edgardo J; Alpe, Terri L et al. (2018) The presence of large focal lesions is a strong independent prognostic factor in multiple myeloma. Blood 132:59-66
Xiong, Jinhu; Almeida, Maria; O'Brien, Charles A (2018) The YAP/TAZ transcriptional co-activators have opposing effects at different stages of osteoblast differentiation. Bone 112:1-9
Wongsurawat, Thidathip; Athipanyasilp, Niracha; Jenjaroenpun, Piroon et al. (2018) Case of Microcephaly after Congenital Infection with Asian Lineage Zika Virus, Thailand. Emerg Infect Dis 24:
Xiong, Jinhu; Cawley, Keisha; Piemontese, Marilina et al. (2018) Soluble RANKL contributes to osteoclast formation in adult mice but not ovariectomy-induced bone loss. Nat Commun 9:2909

Showing the most recent 10 out of 11 publications