This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Cancer disproportionately affects the citizens of West Virginia and Appalachia, as evidenced by health disparities in cervical, lung, head &neck, ovarian and breast cancers. The Mary Babb Randolph Cancer Center (MBRCC) was established at West Virginia University to address this problem. Toward that goal we will establish a cancer center that meets the criteria for NCI designation as a Clinical Cancer Center. In Phase I of our CoBRE funding the MBRCC coordinated cancer center membership and organization of programs, provided matching support for pilot projects, core facilities and lab/office space for new faculty hires. In addition, the CoBRE provided support for five junior faculty research projects, core facility infrastructure and matching funds for faculty recruitment. We successfully recruited 8 faculty members, mentoring 5 junior faculty to independent research project grant (RPG) funding, establishing two new core facilities and expanding the scope of a 3rd core facility. During Phase II we have sought to add depth to our basic science research programs with a long term goal of integrating basic research projects with translational research programs. During the coming year our specific aims include (a) continuation of our Administration Core, (b) support core facilities in Flow Cytometry, Bioinformatics, Imaging and Protein Purification and (c) support five junior faculty research projects and mentor these faculty members to independence. This CoBRE program will foster our long term goal of achieving NCI designation as a Clinical Cancer Center that serves the patient population of West Virginia and the surrounding Appalachian region.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016440-09
Application #
7960373
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Project Start
2009-07-01
Project End
2010-06-30
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
9
Fiscal Year
2009
Total Cost
$417,308
Indirect Cost
Name
West Virginia University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Nichols, Cody E; Shepherd, Danielle L; Hathaway, Quincy A et al. (2018) Reactive oxygen species damage drives cardiac and mitochondrial dysfunction following acute nano-titanium dioxide inhalation exposure. Nanotoxicology 12:32-48
Shumar, Stephanie A; Kerr, Evan W; Geldenhuys, Werner J et al. (2018) Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform. J Biol Chem 293:4134-4148
Bedenbaugh, M N; O'Connell, R C; Lopez, J A et al. (2018) Kisspeptin, gonadotrophin-releasing hormone and oestrogen receptor ? colocalise with neuronal nitric oxide synthase neurones in prepubertal female sheep. J Neuroendocrinol 30:
Rodgers, H M; Huffman, V J; Voronina, V A et al. (2018) The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification. Mech Dev 151:18-29
Brooks, Celine; Snoberger, Aaron; Belcastro, Marycharmain et al. (2018) Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice. J Neurosci 38:7248-7254
Grisez, Brian T; Ray, Justin J; Bostian, Phillip A et al. (2018) Highly metastatic K7M2 cell line: A novel murine model capable of in vivo imaging via luciferase vector transfection. J Orthop Res :
Deng, Wentao; McLaughlin, Sarah L; Klinke, David J (2017) Quantifying spontaneous metastasis in a syngeneic mouse melanoma model using real time PCR. Analyst 142:2945-2953
Alway, Stephen E; McCrory, Jean L; Kearcher, Kalen et al. (2017) Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women. J Gerontol A Biol Sci Med Sci 72:1595-1606
Alway, Stephen E; Mohamed, Junaith S; Myers, Matthew J (2017) Mitochondria Initiate and Regulate Sarcopenia. Exerc Sport Sci Rev 45:58-69
Haramizu, Satoshi; Asano, Shinichi; Butler, David C et al. (2017) Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts. J Nutr Biochem 50:103-115

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