Cancer disproportionately affects the citizens of West Virginia and Appalachia, as evidenced by regional health disparities in cervical, lung, head &neck, ovarian and breast cancers. The Mary Babb Randolph Cancer Center (MBRCC) was established at West Virginia University to address the cancer problem in West Virginia and Appalachia. Toward that goal we plan to establish a cancer center that meets the criteria for NCI designation as a Clinical Cancer Center for our underserved population. NCI designated Cancer Centers were established to lead the fight against cancer as evidenced by (a) strong basic and clinical research programs, (b) an active cancer prevention and control program and (c) an active clinical trials program. The goal of the first phase (Phase I) of our COBRE program was to foster institutional goals for NCI designation as a Clinical Cancer Center through the development of a strong, cohesive and active basic cancer research program. In Phase I, the MBRCC coordinated cancer center membership and organization of programs, provided matching support for pilot projects, Core facilities and laboratory/office space for new faculty hires. In addition, the West Virginia University Health Sciences Center committed tenure-track faculty lines for new faculty hires and resources for startup packages, administrative support, renovations for labs and Core facilities and funds for Core equipment. During Phase I, the COBRE provided support for five junior faculty research projects, Core facility infrastructure for new and existing faculty and matching funds for faculty recruitment. In Phase I, we were successful in recruiting 8 new faculty members, mentoring 5 junior faculty members to independent RPG funding, establishing two new Core facilities and expanding the scope of a 3rd Core facility. In this renewal application (Phase II), we seek to add depth to our basic science research program and to integrate it with translational research initiatives, in an effort to establish an NCI designated Clinical Cancer Center at West Virginia University. We seek support for (1) an administrative Core of experienced cancer research scientists, (2) five cancer research projects led by junior faculty and (3) three Core facilities in proteomics, flow cytometry and bioinformatics that support the MBRCC research programs. Accomplishment of these goals will help the MBRCC to establish an NCI designated Clinical Cancer Center that serves West Virginia and the surrounding Appalachian region.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016440-10
Application #
7893577
Study Section
Special Emphasis Panel (ZRR1-RI-8 (01))
Program Officer
Liu, Yanping
Project Start
2001-09-14
Project End
2011-07-14
Budget Start
2010-07-01
Budget End
2011-07-14
Support Year
10
Fiscal Year
2010
Total Cost
$2,084,768
Indirect Cost
Name
West Virginia University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
191510239
City
Morgantown
State
WV
Country
United States
Zip Code
26506
Nichols, Cody E; Shepherd, Danielle L; Hathaway, Quincy A et al. (2018) Reactive oxygen species damage drives cardiac and mitochondrial dysfunction following acute nano-titanium dioxide inhalation exposure. Nanotoxicology 12:32-48
Shumar, Stephanie A; Kerr, Evan W; Geldenhuys, Werner J et al. (2018) Nudt19 is a renal CoA diphosphohydrolase with biochemical and regulatory properties that are distinct from the hepatic Nudt7 isoform. J Biol Chem 293:4134-4148
Bedenbaugh, M N; O'Connell, R C; Lopez, J A et al. (2018) Kisspeptin, gonadotrophin-releasing hormone and oestrogen receptor ? colocalise with neuronal nitric oxide synthase neurones in prepubertal female sheep. J Neuroendocrinol 30:
Rodgers, H M; Huffman, V J; Voronina, V A et al. (2018) The role of the Rx homeobox gene in retinal progenitor proliferation and cell fate specification. Mech Dev 151:18-29
Brooks, Celine; Snoberger, Aaron; Belcastro, Marycharmain et al. (2018) Archaeal Unfoldase Counteracts Protein Misfolding Retinopathy in Mice. J Neurosci 38:7248-7254
Grisez, Brian T; Ray, Justin J; Bostian, Phillip A et al. (2018) Highly metastatic K7M2 cell line: A novel murine model capable of in vivo imaging via luciferase vector transfection. J Orthop Res :
Alway, Stephen E; Mohamed, Junaith S; Myers, Matthew J (2017) Mitochondria Initiate and Regulate Sarcopenia. Exerc Sport Sci Rev 45:58-69
Haramizu, Satoshi; Asano, Shinichi; Butler, David C et al. (2017) Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts. J Nutr Biochem 50:103-115
Yu, Han-Gang; McLaughlin, Sarah; Newman, Mackenzie et al. (2017) Altering calcium influx for selective destruction of breast tumor. BMC Cancer 17:169
Jones, Brandon C; Kelley, Laura C; Loskutov, Yuriy V et al. (2017) Dual Targeting of Mesenchymal and Amoeboid Motility Hinders Metastatic Behavior. Mol Cancer Res 15:670-682

Showing the most recent 10 out of 306 publications