This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The ABC superfamily is one of the largest known families of proteins. Members of the ABCB and ABCC subfamilies play significant roles in physiology, toxicology, pharmacology, and disease; however, the mechanisms that regulate their expression are not well understood. This project uses comparative sequence analysis strategies to predict putative regulatory sequences in ABCB and ABCC genes. Initial studies focused on noncoding (5' upstream and intron) sequences for the cystic fibrosis transmembrane conductance regulator (CFTR; ABCC7). Examination of available genomic alignment programs suggested that this approach was ineffective for finding regulatory regions in CFTR due to divergence in noncoding regions.

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR016463-06
Application #
7381440
Study Section
Special Emphasis Panel (ZRR1-RI-7 (01))
Project Start
2006-05-01
Project End
2007-04-30
Budget Start
2006-05-01
Budget End
2007-04-30
Support Year
6
Fiscal Year
2006
Total Cost
$106,030
Indirect Cost
Name
Mount Desert Island Biological Lab
Department
Type
DUNS #
077470003
City
Salisbury Cove
State
ME
Country
United States
Zip Code
04672
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