This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The primary goal of this project is to develop virtual environments (VEs) that include different levels of haptic sensory feedback and to evaluate the effectiveness of these applications for neurorehabilitation training. The tasks to be performed within these VEs will span a range of activities from everyday functional tasks to game-like activities designed to motivate specific motor action that is believed to underlie more functional behavior. The outcome of this work will be to create VE applications that will be evaluated for both the usability of the VE interface and display devices by patient populations following stroke and for the impact that training in these environments has on both motor performance and cortical reorganization. In Year 1, we propose to create three VE systems that expand on applications that we have currently in development that use three different types of haptic feedback devices. The haptic devices that we have available can be applied to a progressive set of training tasks from precise fine motor movements, fine and gross motor hand activities and gross reaching movements that involve full arm, shoulder and torso activity. The three systems and tasks are: 1. The PHANTOM (see Haptics Movie on CD) is a small, desk-grounded robot that permits simulation of single or two-fingertip contact with virtual objects through a thimble or stylus. 2. The CyberGrasp (see Haptics Movie on CD) is an exoskeletal device that fits over a 22 DOF CyberGIove, providing force feedback. 3. This application will use vibrating mechanisms on the palm of the hand to simulate contact/collision with moving objects in a series of game based environments designed to exercise gross arm, shoulder and torso movemen

Agency
National Institute of Health (NIH)
Institute
National Center for Research Resources (NCRR)
Type
Exploratory Grants (P20)
Project #
5P20RR020700-03
Application #
7382214
Study Section
Special Emphasis Panel (ZRR1-BT-8 (01))
Project Start
2006-08-01
Project End
2007-07-31
Budget Start
2006-08-01
Budget End
2007-07-31
Support Year
3
Fiscal Year
2006
Total Cost
$88,045
Indirect Cost
Name
University of Southern California
Department
Anatomy/Cell Biology
Type
Schools of Medicine
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Han, Cheol E; Kim, Sujin; Chen, Shuya et al. (2013) Quantifying arm nonuse in individuals poststroke. Neurorehabil Neural Repair 27:439-47
Schweighofer, Nicolas; Han, Cheol E; Wolf, Steven L et al. (2009) A functional threshold for long-term use of hand and arm function can be determined: predictions from a computational model and supporting data from the Extremity Constraint-Induced Therapy Evaluation (EXCITE) Trial. Phys Ther 89:1327-36
Allred, Rachel P; Adkins, DeAnna L; Woodlee, Martin T et al. (2008) The vermicelli handling test: a simple quantitative measure of dexterous forepaw function in rats. J Neurosci Methods 170:229-44
Han, Cheol E; Arbib, Michael A; Schweighofer, Nicolas (2008) Stroke rehabilitation reaches a threshold. PLoS Comput Biol 4:e1000133
Callan, Daniel E; Schweighofer, Nicolas (2008) Positive and negative modulation of word learning by reward anticipation. Hum Brain Mapp 29:237-49
Maldonado, Monica A; Allred, Rachel P; Felthauser, Erik L et al. (2008) Motor skill training, but not voluntary exercise, improves skilled reaching after unilateral ischemic lesions of the sensorimotor cortex in rats. Neurorehabil Neural Repair 22:250-61
Gopalakrishna, Rayudu; Gundimeda, Usha; Schiffman, Jason Eric et al. (2008) A direct redox regulation of protein kinase C isoenzymes mediates oxidant-induced neuritogenesis in PC12 cells. J Biol Chem 283:14430-44
Stewart, Jill Campbell; Yeh, Shih-Ching; Jung, Younbo et al. (2007) Intervention to enhance skilled arm and hand movements after stroke: A feasibility study using a new virtual reality system. J Neuroeng Rehabil 4:21
Schweighofer, Nicolas; Tanaka, Saori C; Doya, Kenji (2007) Serotonin and the evaluation of future rewards: theory, experiments, and possible neural mechanisms. Ann N Y Acad Sci 1104:289-300
Bonaiuto, James; Rosta, Edina; Arbib, Michael (2007) Extending the mirror neuron system model, I. Audible actions and invisible grasps. Biol Cybern 96:9-38

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