Abstract

Public Health Relevance

Genetic risk factors play a major etiologic role in alcoholism. New advances in both human and animal genetics have laid the foundation for potential breakthroughs. This proposal seeks funding for three positions that would add to an active and highly integrated research group to propel forward their efforts to identify the genetic substrate of alcoholism, which could lead to improved prevention and treatment

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Center Core Grants (P30)
Project #
1P30AA019372-01
Application #
7860963
Study Section
Special Emphasis Panel (ZAA1-DD (02))
Program Officer
Reilly, Matthew
Project Start
2009-09-25
Project End
2011-08-31
Budget Start
2009-09-25
Budget End
2010-08-31
Support Year
1
Fiscal Year
2009
Total Cost
$446,540
Indirect Cost

  Institution

Name
Virginia Commonwealth University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298

  Publications

Bull, Cecilia; Syed, Wahab A; Minter, Sabrina C et al. (2015) Differential response of glial fibrillary acidic protein-positive astrocytes in the rat prefrontal cortex following ethanol self-administration. Alcohol Clin Exp Res 39:650-8
Bull, Cecilia; Freitas, Kelen C C; Zou, Shiping et al. (2014) Rat nucleus accumbens core astrocytes modulate reward and the motivation to self-administer ethanol after abstinence. Neuropsychopharmacology 39:2835-45
Brown, Ruth C; Berenz, Erin C; Aggen, Steven H et al. (2014) Trauma Exposure and Axis I Psychopathology: A Co-twin Control Analysis in Norwegian Young Adults. Psychol Trauma 6:652-660
Zhao, Zhongming; Guo, An-Yuan; van den Oord, Edwin J C G et al. (2012) Multi-species data integration and gene ranking enrich significant results in an alcoholism genome-wide association study. BMC Genomics 13 Suppl 8:S16
Kendler, Kenneth S; Kalsi, Gursharan; Holmans, Peter A et al. (2011) Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample. Alcohol Clin Exp Res 35:963-75
Bowers, Michael Scott (2010) Activators of G-protein signaling 3: a drug addiction molecular gateway. Behav Pharmacol 21:500-13