The Optical Imaging Core is a new addition to the arsenal of core facilities available to San Antonio Nathan Shock Center members. The comprehensive studies proposed by members of this Nathan Shock Center increasingly require multi-level, correlative analysis of the physiological processes involved in aging. As such, many studies will involve analysis of cells, tissues, and animals. To aid the progress of aging research the Optical Imaging Core will make state-of-the-art imaging technology available to all Nathan Shock Center investigators. High-end instrumentation for acquisition and analysis of optical data is expensive and requires continued maintenance and improvements. The required commitment to this technology is often difficult to maintain within individual laboratories, especially when optical imaging is not a major focus for the laboratory. Therefore, the Optical Imaging Facility fills a critical need of Nathan Shock Center investigators by housing state-of-the-art technology, by providing continued maintenance of the equipment, and by offering training and technical advice to clients.
The Specific Aims are as follows: 1. To make available to the aging research community at UTHSCSA state-of-the-art optical microscopy technology for imaging of living cells, tissues, and animals. 2. To anticipate and develop new imaging based technology for aging research. 3. To provide consultation, education and assistance regarding the theory and application of optical imaging to ensure the quality of research conducted by Nathan Shock Center clients of the Optical Imaging Core. 4. To provide computer hardware and software for analysis of digital images and production of publication quality prints.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-5 (J1))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Texas Health Science Center San Antonio
San Antonio
United States
Zip Code
Kraig, Ellen; Linehan, Leslie A; Liang, Hanyu et al. (2018) A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects. Exp Gerontol 105:53-69
Ungvari, Zoltan; Tarantini, Stefano; Donato, Anthony J et al. (2018) Mechanisms of Vascular Aging. Circ Res 123:849-867
Weiss, Roxanne; Fernandez, Elizabeth; Liu, Yuhong et al. (2018) Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice. Aging (Albany NY) :
Qin, Kunhua; Zhang, Ning; Zhang, Zhao et al. (2018) SIRT6-mediated transcriptional suppression of Txnip is critical for pancreatic beta cell function and survival in mice. Diabetologia 61:906-918
Salmon, Adam B; Dorigatti, Jonathan; Huber, Hillary F et al. (2018) Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions. Geroscience 40:269-278
Gelfond, Jonathan; Goros, Martin; Hernandez, Brian et al. (2018) A System for an Accountable Data Analysis Process in R. R J 10:6-21
Sills, Aubrey M; Artavia, Joselyn M; DeRosa, Brian D et al. (2018) Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets. Am J Primatol :e22927
Xu, Ming; Pirtskhalava, Tamar; Farr, Joshua N et al. (2018) Senolytics improve physical function and increase lifespan in old age. Nat Med 24:1246-1256
Unnikrishnan, Archana; Hadad, Niran; Masser, Dustin R et al. (2018) Revisiting the genomic hypomethylation hypothesis of aging. Ann N Y Acad Sci 1418:69-79
Van Skike, Candice E; Jahrling, Jordan B; Olson, Angela B et al. (2018) Inhibition of mTOR protects the blood-brain barrier in models of Alzheimer's disease and vascular cognitive impairment. Am J Physiol Heart Circ Physiol 314:H693-H703

Showing the most recent 10 out of 231 publications