The overall goals of the Pittsburgh Claude D. Pepper Older American Independence Center (OAIC), funded since 2004, are to address the critical need to improve mobility, balance, and falls risk, both through improved understanding of their causes and through development of preventive and therapeutic interventions. With this renewal we also will extend our work into new and high potential areas and bring several innovations to our activities and Cores.
Our specific aims for the next 5 years are to: 1) Promote multidisciplinary research into the causes, consequences and treatment of age-related changes in mobility and balance. 2) Build on the exceptional expertise of our research team to extend our work into two new high potential areas: a) the mechanisms that mediate interactions between multiple body tissues/organelles (nerve, muscle, bone, fat; mitochondria), and their impact on mobility and gait; and b) health system and community (including long-term care) adoption of interventions to enhance mobility and balance 3) Train young investigators from multiple disciplines in an intellectually vibrant, collaborative environment with a new KL2 program aligned with our successful Clinical and Translational Science Institute. 4) Serve as a resource and partner to investigators, research programs, institutions, OAICs and the public. Our accomplishments and future plans are built on a set of enduring fundamental beliefs and values: 1) a theme (mobility and balance) that is cohesive yet accommodates a broad range of approaches and needs, 2) a commitment to multidisciplinary research, 3) a stable organization that can grow and evolve, and 4) rigorous preparation of the next generation of investigators and leaders. To accomplish these aims, our OAIC is built around 6 cores. In addition to the Leadership and Administrative Core and Research Career Development KL2 Component, we have a Pilot and Exploratory Studies Core, and 3 Resource Cores: a Clinical and Population Outcomes Core, an Integrative Systems Core and a Data Management, Analysis and Informatics Core. In the first year of the renewal, we will support 2 Pepper KL2 Scholars, 4 pilot projects, and 3 developmental projects that illustrate the scope and innovation of our work.

Public Health Relevance

Mobility and balance disorders are common among the aged and contribute to reduced physical activity, falls, injuries, disability, loss of independence, and health care utilization. Our multidisciplinary group of collaborative investigators are dedicated to foster optimal mobility and balance among older American and develop preventive and therapeutic interventions to reduce falls and maintain independence.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Program Officer
Eldadah, Basil A
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Pittsburgh
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Rosso, Andrea L; Bohnen, Nicolaas I; Launer, Lenore J et al. (2018) Vascular and dopaminergic contributors to mild parkinsonian signs in older adults. Neurology 90:e223-e229
Agimi, Yll; Albert, Steven M; Youk, Ada O et al. (2018) Mandatory Physician Reporting of At-Risk Drivers: The Older Driver Example. Gerontologist 58:578-587
Bon, Jessica; Zhang, Yingze; Leader, Joseph K et al. (2018) Radiographic Emphysema, Circulating Bone Biomarkers, and Progressive Bone Mineral Density Loss in Smokers. Ann Am Thorac Soc 15:615-621
Best, John R; Liu-Ambrose, Teresa; Metti, Andrea L et al. (2018) Longitudinal Associations Between Walking Speed and Amount of Self-reported Time Spent Walking Over a 9-Year Period in Older Women and Men. J Gerontol A Biol Sci Med Sci 73:1265-1271
Yuan, Jian-Min; Beckman, Kenneth B; Wang, Renwei et al. (2018) Leukocyte telomere length in relation to risk of lung adenocarcinoma incidence: Findings from the Singapore Chinese Health Study. Int J Cancer 142:2234-2243
Metti, Andrea L; Best, John R; Shaaban, C Elizabeth et al. (2018) Longitudinal changes in physical function and physical activity in older adults. Age Ageing :
Hayden, Kathleen M; Baker, Laura D; Bray, George et al. (2018) Long-term impact of intensive lifestyle intervention on cognitive function assessed with the National Institutes of Health Toolbox: The Look AHEAD study. Alzheimers Dement (Amst) 10:41-48
Sparto, Patrick J; Newman, A B; Simonsick, E M et al. (2018) Contributions to lateral balance control in ambulatory older adults. Aging Clin Exp Res 30:633-641
Lee, Sei J; Larson, Eric B; Dublin, Sascha et al. (2018) A Cohort Study of Healthcare Utilization in Older Adults with Undiagnosed Dementia. J Gen Intern Med 33:13-15
Urbanek, Jacek K; Zipunnikov, Vadim; Harris, Tamara et al. (2018) Prediction of sustained harmonic walking in the free-living environment using raw accelerometry data. Physiol Meas 39:02NT02

Showing the most recent 10 out of 1292 publications