The overall goal of the proposed Arkansas Older Americans Independence Center (OAIC) is to promote the translation of basic and physiological research on cardiac and skeletal muscle dysfunction in aging and disease to clinically relevant outcomes that ultimately have a positive influence on the standard of care. A particular emphasis will be nutritional approaches to ameliorating the physiological impact of changes in muscle metabolism. The fundamental strategy centers on determining the metabolic basis for observed catabolic responses in order to design and test approaches to counteract these responses. Stable isotope tracer methodology is uniquely suited to advance this overall goal of the Arkansas OAIC. Stable isotope tracer methodology can be used in the most basic in vitro studies and in small animal studies to quantify metabolic reactions, and the same methodology can be extended to human studies. A number of clinical outcome studies have validated the success of acute tracer studies of muscle metabolism in predicting longterm outcomes (e.g., references. 1,2). Consequently, the Analytical Core's primary goal will be to support the performance of stable isotope tracer experiments, including sample and data analysis, and to continue to develop new methodologies, as needed, to support studies related to therapeutic nutrition and aging, with particular emphasis on issues related to skeletal and cardiac muscle dysfunction associated with aging and/or congestive heart failure (CHF), including the condition of cardiac cachexia. We will also actively train investigators on stable isotope tracer methodology.

Public Health Relevance

Quantification of metabolic rates by the use of stable isotope tracer methods can be accomplished in a matter of a few hours in human subjects. These studies enable the development of new approaches which can subsequently be tested in long-term outcome studies. Thus stable isotope tracer methodology can serve as the cornerstone in translating basic metabolic research into practical approaches of value to the general population of aging individuals.

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1-ZIJ-8)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Arkansas for Medical Sciences
Little Rock
United States
Zip Code
Yu, Li-Rong; Cao, Zhijun; Makhoul, Issam et al. (2018) Immune response proteins as predictive biomarkers of doxorubicin-induced cardiotoxicity in breast cancer patients. Exp Biol Med (Maywood) 243:248-255
Coker, Robert H; Wolfe, Robert R (2018) Weight Loss Strategies in the Elderly: A Clinical Conundrum. Obesity (Silver Spring) 26:22-28
Fonseca, Ana Catarina R G; Carvalho, Eugénia; Eriksson, Jan W et al. (2018) Calcineurin is an important factor involved in glucose uptake in human adipocytes. Mol Cell Biochem 445:157-168
George, Masil; Azhar, Gohar; Pangle, Amanda et al. (2017) Feasibility of Conducting a 6-month long Home-based Exercise Program with Protein Supplementation in Elderly Community-dwelling Individuals with Heart Failure. J Physiother Phys Rehabil 2:
Tarantini, Stefano; Tran, Cam Ha T; Gordon, Grant R et al. (2017) Impaired neurovascular coupling in aging and Alzheimer's disease: Contribution of astrocyte dysfunction and endothelial impairment to cognitive decline. Exp Gerontol 94:52-58
Hamarsland, Håvard; Nordengen, Anne Lene; Nyvik Aas, Sigve et al. (2017) Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: a randomized controlled trial. J Int Soc Sports Nutr 14:43
Moura, João; Rodrigues, João; Gonçalves, Marta et al. (2017) Impaired T-cell differentiation in diabetic foot ulceration. Cell Mol Immunol 14:758-769
Burgeiro, Ana; Cerqueira, Manuela G; Varela-Rodríguez, Bárbara M et al. (2017) Glucose and Lipid Dysmetabolism in a Rat Model of Prediabetes Induced by a High-Sucrose Diet. Nutrients 9:
Tarantini, Stefano; Valcarcel-Ares, Noa M; Yabluchanskiy, Andriy et al. (2017) Insulin-like growth factor 1 deficiency exacerbates hypertension-induced cerebral microhemorrhages in mice, mimicking the aging phenotype. Aging Cell 16:469-479
Zhang, Xiaomin; Azhar, Gohar; Wei, Jeanne Y (2017) SIRT2 gene has a classic SRE element, is a downstream target of serum response factor and is likely activated during serum stimulation. PLoS One 12:e0190011

Showing the most recent 10 out of 81 publications