Inflammatory biology plays a central role in illness and disability among older people. The OAIC Inflammatory Biology Core (IBC) at UCLA will provide intellectual and technical support for the analysis of inflammatory dynamics in Pepper Center research programs. In addition to conventional blood-based measures of inflammatory markers, the IBC will also provide extensive molecular biology infrastructure for mapping upstream signaling processes that cause aberrant inflammation, and for defining the down-stream impact of inflammatory signaling on target tissues. IBC analytic infrastructure will expand information yield from six currently funded Pepper Center R01s (e.g., immune dysregulation in aging, effects of cancer therapy on cognitive function in the elderly, and cytokine effects on sleep in healthy elderly), and facilitate analysis of inflammatory dynamics in newly-developed Pepper Center research programs (pilot projects in the OAIC Pilot and Exploratory Core and new R01s emerging from the Center). The Core will generate new technical approaches for assessing molecular bases of inflammatory signaling during aging, measuring functional impacts of genetic polymorphisms, and monitoring the activity proinflammatory cytokines and hormones using genomics-based biomarkers. The OAIC IBC includes multi-disciplinary intellectual support (behavior, genetics, and immunology), vertical integration of inflammatory biology into the full range of research program development, training in molecular analyses of inflammation, and development of new strategies for assessing the sources and targets of inflammatory signals in aging individuals.
Three specific aims are proposed: 1) Expand and support the analysis of inflammatory biology in existing UCLA OAIC research programs and in new OAIC pilot projects and developing research programs;2) Develop new analytic approaches to facilitate in vivo analysis of inflammatory dynamics and their functional genomic impact on elderly individuals;3) Provide training in behavioral, immunologic, and molecular aspects of inflammatory biology in general, and as they pertain to the unique health and function issues in aging. This training will emphasize biological knowledge about the sources and targets of inflammatory signals, and their role in the health and functional independence of older people..

National Institute of Health (NIH)
National Institute on Aging (NIA)
Center Core Grants (P30)
Project #
Application #
Study Section
Special Emphasis Panel (ZAG1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of California Los Angeles
Los Angeles
United States
Zip Code
Kim, Seungyoun; Spilman, Samantha L; Liao, Diana H et al. (2018) Social networks and alcohol use among older adults: a comparison with middle-aged adults. Aging Ment Health 22:550-557
Goldwater, Deena; Karlamangla, Arun; Merkin, Sharon Stein et al. (2018) Interleukin-10 as a predictor of major adverse cardiovascular events in a racially and ethnically diverse population: Multi-Ethnic Study of Atherosclerosis. Ann Epidemiol :
Kuerbis, Alexis; Reid, M Carrington; Lake, Jordan E et al. (2018) Daily Factors Driving Daily Substance Use and Chronic Pain among Older Adults with HIV: An Exploratory Study Using Ecological Momentary Assessment. Alcohol :
Majeno, Angelina; Tsai, Kim M; Huynh, Virginia W et al. (2018) Discrimination and Sleep Difficulties during Adolescence: The Mediating Roles of Loneliness and Perceived Stress. J Youth Adolesc 47:135-147
Zonis, Svetlana; Breunig, Joshua J; Mamelak, Adam et al. (2018) Inflammation-induced Gro1 triggers senescence in neuronal progenitors: effects of estradiol. J Neuroinflammation 15:260
Tsai, Kim M; Dahl, Ronald E; Irwin, Michael R et al. (2018) The Roles of Parental Support and Family Stress in Adolescent Sleep. Child Dev 89:1577-1588
Hernandez, Rosalba; Cheung, Elaine; Liao, Minli et al. (2018) The Association Between Depressive Symptoms and Cognitive Functioning in Older Hispanic/Latino Adults Enrolled in an Exercise Intervention: Results From the ""¡Caminemos!"" Study. J Aging Health 30:843-862
Chiang, Jessica J; Ko, Ahra; Bower, Julienne E et al. (2018) Stress, Psychological Resources, and HPA and Inflammatory Reactivity During Late Adolescence. Dev Psychopathol :1-14
Lê-Scherban, Félice; Brenner, Allison B; Hicken, Margaret T et al. (2018) Child and Adult Socioeconomic Status and the Cortisol Response to Acute Stress: Evidence From the Multi-Ethnic Study of Atherosclerosis. Psychosom Med 80:184-192
Hsu, Jeffrey J; Lu, Jinxiu; Umar, Soban et al. (2018) Effects of teriparatide on morphology of aortic calcification in aged hyperlipidemic mice. Am J Physiol Heart Circ Physiol 314:H1203-H1213

Showing the most recent 10 out of 384 publications