Abstract

The Oligonucleotide and Polypeptide Synthesis Facility is already established but the additional reagents required by the numbers of this Center will require additional personnel and supplies. A second oligonucleotide synthesizer has already been purchased in anticipation of this need. Oligonucleotides are used to sequence antibody and viral genes. Peptides are required for immunization and especially for screening for antibodies that react with epitopes.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027741-05
Application #
3791383
Study Section
Project Start
Project End
Budget Start
Budget End
Support Year
5
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
Albert Einstein College of Medicine
Department
Type
DUNS #
009095365
City
Bronx
State
NY
Country
United States
Zip Code
10461

  Publications

Rubinstein, Arye (2005) Preclinical studies of alkylureas as anti-HIV-1 contraceptive. Curr Pharm Des 11:3769-78
Lenz, J; Su, M; Mizrachi, Y et al. (2001) V3 variation in HIV-seropositive patients receiving a V3- targeted vaccine. AIDS 15:577-81
Browning Paul, J; Wang, E J; Pettoello-Mantovani, M et al. (2000) Mice transgenic for monocyte-tropic HIV type 1 produce infectious virus and display plasma viremia: a new in vivo system for studying the postintegration phase of HIV replication. AIDS Res Hum Retroviruses 16:481-92
Rubinstein, A; Mizrachi, Y; Bernstein, L et al. (2000) Progressive specific immune attrition after primary, secondary and tertiary immunizations with bacteriophage phi X174 in asymptomatic HIV-1 infected patients. AIDS 14:F55-62
Yurasov, S V; Pettoello-Mantovani, M; Raker, C A et al. (1999) HIV type 1 infection of human fetal bone marrow cells induces apoptotic changes in hematopoietic precursor cells and suppresses their in vitro differentiation and capacity to engraft SCID mice. AIDS Res Hum Retroviruses 15:1639-52
Rubinstein, A; Mizrachi, Y; Pettoello-Mantovani, M et al. (1999) Immunologic responses of HIV-1-infected study subjects to immunization with a mixture of peptide protein derivative-V3 loop peptide conjugates. J Acquir Immune Defic Syndr 22:467-76
Pettoello-Mantovani, M; Kollmann, T R; Katopodis, N F et al. (1998) thy/liv-SCID-hu mice: a system for investigating the in vivo effects of multidrug therapy on plasma viremia and human immunodeficiency virus replication in lymphoid tissues. J Infect Dis 177:337-46
Landor, M; Rubinstein, A; Kim, A et al. (1998) Receptor-mediated maternofetal transfer of immunoglobulins. Inhibition of transport of anti-HIV-1 immunoglobulin by generic immunoglobulins in the in vitro perfused placenta. Int Arch Allergy Immunol 115:203-9
Browning, J; Horner, J W; Pettoello-Mantovani, M et al. (1997) Mice transgenic for human CD4 and CCR5 are susceptible to HIV infection. Proc Natl Acad Sci U S A 94:14637-41
Harish, Z; Rubinstein, A; Golodner, M et al. (1997) Suppression of HIV-1 replication by propolis and its immunoregulatory effect. Drugs Exp Clin Res 23:89-96

Showing the most recent 10 out of 36 publications