Cancer is increasingly recognized as an important complication of HIV infection, with -10% of HIV-infected persons expected to develop cancer at some point in their lifetime. For many HIV-associated malignancies (HIVAM), few good strategies for prevention or treatment exist. Seattle has developed an extraordinary community of researchers in both cancer and HIV, and over the last five years the AIDS-Associated Infections and Malignancies (AAlMs) Scientific Working Group has been highly successful in bringing together these research communities to address HIVAM. We now propose to expand the activities of the AAlMs group to become a Core in the UW/FHCRC CFAR, with three Specific Aims: 1) Enable studies of HIVAM through the development and deployment of assays for the molecular detection and quantification of viral oncogens; 2) Facilitate the diagnosis of HIVAM, as well as detailed studies of HIVAM pathogenesis, in CFAR-affiliated HIV cohorts through the provision of a suite of molecular and immunohistochemical tumor assays; 3) Disseminate data instruments to accurately identify and characterize cancer endpoints among HIV-infected persons participating in CFAR-affiliated research studies. To achieve these goals, we have assembled a group of international experts from the Fred Hutchinson Cancer Research Center and the University of Washington to serve on the Core's Steering Committee, leveraged the highly successful Molecular Diagnostics Laboratories in Seattle and Uganda, expanded core pathology diagnostic services offered by the Hutchinson Center and the Seattle Cancer Care Alliance, and utilized the expertise in data collection of the Statistical Center for HIV/AIDS Research & Prevention.

Public Health Relevance

Cancer is a common complication of HIV infection, and better strategies for cancer prevention and treatment are needed. The AIDS-Associated Infections and Malignancies Core will facilitate innovative research in cancer among persons with HIV infection by offering investigators molecular, diagnostic and data tools to increase the scope, quantity and quality of cancer research in cohorts of HIV-infected individuals.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Center Core Grants (P30)
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University of Washington
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Fredericksen, R J; Gibbons, L; Brown, S et al. (2018) Medication understanding among patients living with multiple chronic conditions: Implications for patient-reported measures of adherence. Res Social Adm Pharm 14:540-544
AIDS-defining Cancer Project Working Group of IeDEA, COHERE in EuroCoord (2018) Non-Hodgkin lymphoma risk in adults living with HIV across five continents. AIDS 32:2777-2786
Morgan, Ethan; Skaathun, Britt; Schneider, John A (2018) Sexual, Social, and Genetic Network Overlap: A Socio-Molecular Approach Toward Public Health Intervention of HIV. Am J Public Health 108:1528-1534
Velonjara, Julia; Crouthamel, Bonnie; O'Malley, Gabrielle et al. (2018) Motherhood increases support for family planning among Kenyan adolescents. Sex Reprod Healthc 16:124-131
Liu, Amy Y; De Rosa, Stephen C; Guthrie, Brandon L et al. (2018) High background in ELISpot assays is associated with elevated levels of immune activation in HIV-1-seronegative individuals in Nairobi. Immun Inflamm Dis 6:392-401
OhAinle, Molly; Helms, Louisa; Vermeire, Jolien et al. (2018) A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV. Elife 7:
Simoni, Jane M; Ronen, Keshet; Aunon, Frances M (2018) Health Behavior Theory to Enhance eHealth Intervention Research in HIV: Rationale and Review. Curr HIV/AIDS Rep 15:423-430
Layton, Erik D; Yu, Krystle K Q; Smith, Malisa T et al. (2018) Validation of a CD1b tetramer assay for studies of human mycobacterial infection or vaccination. J Immunol Methods 458:44-52
Murphy, Sean C; Ishizuka, Andrew S; Billman, Zachary P et al. (2018) Plasmodium 18S rRNA of intravenously administered sporozoites does not persist in peripheral blood. Malar J 17:275
Korhonen, Christine; Kimani, Makobu; Wahome, Elizabeth et al. (2018) Depressive symptoms and problematic alcohol and other substance use in 1476 gay, bisexual, and other MSM at three research sites in Kenya. AIDS 32:1507-1515

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