Cancer is increasingly recognized as an important complication of HIV infection, with -10% of HIV-infected persons expected to develop cancer at some point in their lifetime. For many HIV-associated malignancies (HIVAM), few good strategies for prevention or treatment exist. Seattle has developed an extraordinary community of researchers in both cancer and HIV, and over the last five years the AIDS-Associated Infections and Malignancies (AAlMs) Scientific Working Group has been highly successful in bringing together these research communities to address HIVAM. We now propose to expand the activities of the AAlMs group to become a Core in the UW/FHCRC CFAR, with three Specific Aims: 1) Enable studies of HIVAM through the development and deployment of assays for the molecular detection and quantification of viral oncogens; 2) Facilitate the diagnosis of HIVAM, as well as detailed studies of HIVAM pathogenesis, in CFAR-affiliated HIV cohorts through the provision of a suite of molecular and immunohistochemical tumor assays; 3) Disseminate data instruments to accurately identify and characterize cancer endpoints among HIV-infected persons participating in CFAR-affiliated research studies. To achieve these goals, we have assembled a group of international experts from the Fred Hutchinson Cancer Research Center and the University of Washington to serve on the Core's Steering Committee, leveraged the highly successful Molecular Diagnostics Laboratories in Seattle and Uganda, expanded core pathology diagnostic services offered by the Hutchinson Center and the Seattle Cancer Care Alliance, and utilized the expertise in data collection of the Statistical Center for HIV/AIDS Research & Prevention.

Public Health Relevance

Cancer is a common complication of HIV infection, and better strategies for cancer prevention and treatment are needed. The AIDS-Associated Infections and Malignancies Core will facilitate innovative research in cancer among persons with HIV infection by offering investigators molecular, diagnostic and data tools to increase the scope, quantity and quality of cancer research in cohorts of HIV-infected individuals.

Agency
National Institute of Health (NIH)
Institute
National Institute of Allergy and Infectious Diseases (NIAID)
Type
Center Core Grants (P30)
Project #
5P30AI027757-30
Application #
9285719
Study Section
Special Emphasis Panel (ZAI1-UKS-A)
Project Start
Project End
Budget Start
2017-06-01
Budget End
2018-05-31
Support Year
30
Fiscal Year
2017
Total Cost
$295,992
Indirect Cost
$1,257
Name
University of Washington
Department
Type
Domestic Higher Education
DUNS #
605799469
City
Seattle
State
WA
Country
United States
Zip Code
98195
Roberts, Sarah T; Flaherty, Brian P; Deya, Ruth et al. (2018) Patterns of Gender-Based Violence and Associations with Mental Health and HIV Risk Behavior Among Female Sex Workers in Mombasa, Kenya: A Latent Class Analysis. AIDS Behav 22:3273-3286
Duarte, Horacio A; Beck, Ingrid A; Levine, Molly et al. (2018) Implementation of a point mutation assay for HIV drug resistance testing in Kenya. AIDS 32:2301-2308
Herbeck, Joshua T; Peebles, Kathryn; Edlefsen, Paul T et al. (2018) HIV population-level adaptation can rapidly diminish the impact of a partially effective vaccine. Vaccine 36:514-520
Shapiro, Adrienne E; van Heerden, Alastair; Schaafsma, Torin T et al. (2018) Completion of the tuberculosis care cascade in a community-based HIV linkage-to-care study in South Africa and Uganda. J Int AIDS Soc 21:
Bull, Marta E; Mitchell, Caroline; Soria, Jaime et al. (2018) Monotypic low-level HIV viremias during antiretroviral therapy are associated with disproportionate production of X4 virions and systemic immune activation. AIDS 32:1389-1401
Mugwanya, Kenneth K; Baeten, Jared M; Wyatt, Christina et al. (2018) Brief Report: Frequency of Monitoring Kidney Function in HIV-Uninfected Persons Using Daily Oral Tenofovir Disoproxil Fumarate Pre-exposure Prophylaxis. J Acquir Immune Defic Syndr 77:206-211
Hamilton, Deven T; Goodreau, Steven M; Jenness, Samuel M et al. (2018) Potential Impact of HIV Preexposure Prophylaxis Among Black and White Adolescent Sexual Minority Males. Am J Public Health 108:S284-S291
Bilal, Usama; McCaul, Mary E; Crane, Heidi M et al. (2018) Predictors of Longitudinal Trajectories of Alcohol Consumption in People with HIV. Alcohol Clin Exp Res 42:561-570
Morgan, Ethan; Skaathun, Britt; Duvoisin, Rebeccah et al. (2018) Are HIV Seroconversions Among Young Men Who Have Sex With Men Associated With Social Network Proximity to Recently or Long-Term HIV-Infected Individuals? J Acquir Immune Defic Syndr 77:128-134
Beima-Sofie, Kristin; Wamalwa, Dalton; Maleche-Obimbo, Elizabeth et al. (2018) Toll-like receptor 9 polymorphism is associated with increased Epstein-Barr virus and Cytomegalovirus acquisition in HIV-exposed infants. AIDS 32:267-270

Showing the most recent 10 out of 1275 publications