Abstract

To address the knowledge gap discussed previously, NIH is initiating a national research program focused on pediatric SARS-CoV-2, COVID-19 and MIS-C. This goal of the program is to gain comprehensive understanding of phenotype, natural history, outcomes, and pathobiology of MIS-C. The Program will have several components including a MIS-C Cohort Study, adaptive design trials, long-term follow-up and a robust cloud-based data platform. The PHN DCC will serve to coordinate some of the components of the Program.
The Specific Aims of the DCC are as follows:
AIM 1 : MANAGE CORE PROGRAM OPERATIONS AIM 2: MANAGE MIS-C COHORT STUDY DEVELOPMENT, LAUNCH, AND DISSEMINATION OF RESULTS AIM 3: PROVIDE SUPPORT SERVICES TO PROGRAM COMPONENTS

Public Health Relevance

To address the knowledge gap discussed previously, NIH is initiating a national research program focused on pediatric SARS-CoV-2, COVID-19 and MIS-C. This goal of the program is to gain comprehensive understanding of phenotype, natural history, outcomes, and pathobiology of MIS-C. The Program will have several components including a MIS-C Cohort Study, adaptive design trials, long-term follow-up and a robust cloud-based data platform. The PHN DCC will serve to coordinate some of the components of the Program.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
3U24HL135691-03S3
Application #
10202823
Study Section
Program Officer
Schramm, Charlene A
Project Start
2020-08-04
Project End
2020-12-31
Budget Start
2020-08-04
Budget End
2020-12-31
Support Year
3
Fiscal Year
2020
Total Cost
Indirect Cost

  Institution

Name
New England Research Institute
Department
Type
DUNS #
153914080
City
Watertown
State
MA
Country
United States
Zip Code
02472

  Publications

Mussatto, Kathleen A; Hollenbeck-Pringle, Danielle; Trachtenberg, Felicia et al. (2018) Utilisation of early intervention services in young children with hypoplastic left heart syndrome. Cardiol Young 28:126-133
Zak, Victor; Hsu, Daphne T; Pemberton, Victoria L et al. (2017) Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network Infant Single Ventricle Trial. Cardiol Young 27:1265-1270
Ramroop, Ronand; Manase, George; Lu, Danny et al. (2017) Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial. J Thorac Cardiovasc Surg 154:1703-1710.e3
Lopez, Leo; Colan, Steven; Stylianou, Mario et al. (2017) Relationship of Echocardiographic Z Scores Adjusted for Body Surface Area to Age, Sex, Race, and Ethnicity: The Pediatric Heart Network Normal Echocardiogram Database. Circ Cardiovasc Imaging 10:
Meza, James M; Hickey, Edward J; Blackstone, Eugene H et al. (2017) The Optimal Timing of Stage 2 Palliation for Hypoplastic Left Heart Syndrome: An Analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial Public Data Set. Circulation 136:1737-1748
Im, K; Guimaraes, A; Kim, Y et al. (2017) Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities. AJNR Am J Neuroradiol 38:1449-1455
Marami, Bahram; Mohseni Salehi, Seyed Sadegh; Afacan, Onur et al. (2017) Temporal slice registration and robust diffusion-tensor reconstruction for improved fetal brain structural connectivity analysis. Neuroimage 156:475-488
Lambert, Linda M; Trachtenberg, Felicia L; Pemberton, Victoria L et al. (2017) Passive range of motion exercise to enhance growth in infants following the Norwood procedure: a safety and feasibility trial. Cardiol Young 27:1361-1368
Selamet Tierney, Elif Seda; Hollenbeck-Pringle, Danielle; Lee, Caroline K et al. (2017) Reproducibility of Left Ventricular Dimension Versus Area Versus Volume Measurements in Pediatric Patients With Dilated Cardiomyopathy. Circ Cardiovasc Imaging 10:
Margossian, Renee; Zak, Victor; Shillingford, Amanda J et al. (2017) The Effect of the Superior Cavopulmonary Anastomosis on Ventricular Remodeling in Infants with Single Ventricle. J Am Soc Echocardiogr 30:699-707.e1

Showing the most recent 10 out of 11 publications