New England Research Institutes, Inc. (NERI) is applying to continue its 15-year role as the Data Coordinating Center (DCC) for the Pediatric Heart Network (PHN). The PHN is a cooperative network of Core and Auxiliary Clinical Centers, a DCC, and National Heart, Lung and Blood Institute (NHLBI) Project Scientists. The objectives of the PHN DCC are to 1) manage study development, launch, and dissemination of results; 2) manage core PHN operations; and 3) coordinate logistics and other support services. As the DCC, NERI will provide robust scientific oversight and proven logistical support for the next cycle of the Network, with key responsibilities and functions for leadership in project management of the Network, overall study coordination and efficient management of data acquisition; leadership in development and deployment of innovative infrastructure and tools; electronic information and data systems; logistical and support services; novel study design and statistical methodologies; and management and distribution of Network funds. Our proposed approach presents a strong experienced NERI team, which builds upon decades of successful close collaboration with NHLBI, and ensures efficient scientific and administrative support to the PHN, using 21st century technologies. A multiple PI leadership plan is proposed to continue the leadership roles shared by Ms. Miller (Network Operations) and Dr. Stark (Statistics), with clearly delineated roles and responsibilities for leading and directing the DCC.

Public Health Relevance

The mission of the Pediatric Heart Network is to improve health outcomes in patients with pediatric acquired and congenital heart disease; disseminate collaborative findings as the basis for improved evidence- based treatment options and standards of care; train and educate new investigators, and provide support and advocacy for families during the conduct of excellent, ethical clinical research. The Data Coordinating Center provides the network infrastructure to support this research.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Resource-Related Research Projects--Cooperative Agreements (U24)
Project #
5U24HL135691-02
Application #
9521824
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Pemberton, Victoria
Project Start
2017-07-01
Project End
2024-06-30
Budget Start
2018-07-01
Budget End
2019-06-30
Support Year
2
Fiscal Year
2018
Total Cost
Indirect Cost
Name
New England Research Institute
Department
Type
DUNS #
153914080
City
Watertown
State
MA
Country
United States
Zip Code
Mussatto, Kathleen A; Hollenbeck-Pringle, Danielle; Trachtenberg, Felicia et al. (2018) Utilisation of early intervention services in young children with hypoplastic left heart syndrome. Cardiol Young 28:126-133
Lopez, Leo; Colan, Steven; Stylianou, Mario et al. (2017) Relationship of Echocardiographic Z Scores Adjusted for Body Surface Area to Age, Sex, Race, and Ethnicity: The Pediatric Heart Network Normal Echocardiogram Database. Circ Cardiovasc Imaging 10:
Meza, James M; Hickey, Edward J; Blackstone, Eugene H et al. (2017) The Optimal Timing of Stage 2 Palliation for Hypoplastic Left Heart Syndrome: An Analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial Public Data Set. Circulation 136:1737-1748
Im, K; Guimaraes, A; Kim, Y et al. (2017) Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities. AJNR Am J Neuroradiol 38:1449-1455
Marami, Bahram; Mohseni Salehi, Seyed Sadegh; Afacan, Onur et al. (2017) Temporal slice registration and robust diffusion-tensor reconstruction for improved fetal brain structural connectivity analysis. Neuroimage 156:475-488
Lambert, Linda M; Trachtenberg, Felicia L; Pemberton, Victoria L et al. (2017) Passive range of motion exercise to enhance growth in infants following the Norwood procedure: a safety and feasibility trial. Cardiol Young 27:1361-1368
Selamet Tierney, Elif Seda; Hollenbeck-Pringle, Danielle; Lee, Caroline K et al. (2017) Reproducibility of Left Ventricular Dimension Versus Area Versus Volume Measurements in Pediatric Patients With Dilated Cardiomyopathy. Circ Cardiovasc Imaging 10:
Margossian, Renee; Zak, Victor; Shillingford, Amanda J et al. (2017) The Effect of the Superior Cavopulmonary Anastomosis on Ventricular Remodeling in Infants with Single Ventricle. J Am Soc Echocardiogr 30:699-707.e1
Zak, Victor; Hsu, Daphne T; Pemberton, Victoria L et al. (2017) Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network Infant Single Ventricle Trial. Cardiol Young 27:1265-1270
Ramroop, Ronand; Manase, George; Lu, Danny et al. (2017) Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial. J Thorac Cardiovasc Surg 154:1703-1710.e3

Showing the most recent 10 out of 11 publications