This supplement will fund junior investigators within the NHLBI-funded Pediatric Heart Network (PHN), to conduct clinical studies in individuals who have Down syndrome and congenital heart disease (CHD). The competitive review yielded six superb projects, two of which will be funded by the INCLUDE supplement (*) and the other four through the PHN Scholar funds. The six meritorious studies are: ? Dr. Stephanie Gaydos (MUSC): The Effect of Congenital Heart Disease on Employment, Neuropsychological Outcomes and Quality of Life in Adults with Down syndrome ? Dr. Matthew Jolley (CHOP): Computer Modeling of the Complete Atrioventricular Canal Valve in Down syndrome ? Dr. Barbara Achuff (TCH): A Multi-Center Prospective Case Controlled Comparison of Analgesia and Sedation after Cardiac Surgery between Children with Down syndrome and their Non-syndromic Counterparts ? Dr. Adam Ware (Utah): Vascular Health and Risk Factors in Children with Down syndrome ? *Dr. Sarah Goldberg (Boston): Risk factors and outcomes in adolescent and adults with CHD with Down syndrome undergoing surgery ? *Dr. Lydia Wright (CHOA): Long term survival in Down syndrome and CHD

National Institute of Health (NIH)
National Heart, Lung, and Blood Institute (NHLBI)
Resource-Related Research Projects--Cooperative Agreements (U24)
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Application #
Study Section
Special Emphasis Panel (ZHL1)
Program Officer
Pemberton, Victoria
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New England Research Institute
United States
Zip Code
Mussatto, Kathleen A; Hollenbeck-Pringle, Danielle; Trachtenberg, Felicia et al. (2018) Utilisation of early intervention services in young children with hypoplastic left heart syndrome. Cardiol Young 28:126-133
Zak, Victor; Hsu, Daphne T; Pemberton, Victoria L et al. (2017) Translating clinical trials into clinical practice: a survey assessing the potential impact of the Pediatric Heart Network Infant Single Ventricle Trial. Cardiol Young 27:1265-1270
Ramroop, Ronand; Manase, George; Lu, Danny et al. (2017) Adrenergic receptor genotypes influence postoperative outcomes in infants in the Single-Ventricle Reconstruction Trial. J Thorac Cardiovasc Surg 154:1703-1710.e3
Lopez, Leo; Colan, Steven; Stylianou, Mario et al. (2017) Relationship of Echocardiographic Z Scores Adjusted for Body Surface Area to Age, Sex, Race, and Ethnicity: The Pediatric Heart Network Normal Echocardiogram Database. Circ Cardiovasc Imaging 10:
Meza, James M; Hickey, Edward J; Blackstone, Eugene H et al. (2017) The Optimal Timing of Stage 2 Palliation for Hypoplastic Left Heart Syndrome: An Analysis of the Pediatric Heart Network Single Ventricle Reconstruction Trial Public Data Set. Circulation 136:1737-1748
Im, K; Guimaraes, A; Kim, Y et al. (2017) Quantitative Folding Pattern Analysis of Early Primary Sulci in Human Fetuses with Brain Abnormalities. AJNR Am J Neuroradiol 38:1449-1455
Marami, Bahram; Mohseni Salehi, Seyed Sadegh; Afacan, Onur et al. (2017) Temporal slice registration and robust diffusion-tensor reconstruction for improved fetal brain structural connectivity analysis. Neuroimage 156:475-488
Lambert, Linda M; Trachtenberg, Felicia L; Pemberton, Victoria L et al. (2017) Passive range of motion exercise to enhance growth in infants following the Norwood procedure: a safety and feasibility trial. Cardiol Young 27:1361-1368
Selamet Tierney, Elif Seda; Hollenbeck-Pringle, Danielle; Lee, Caroline K et al. (2017) Reproducibility of Left Ventricular Dimension Versus Area Versus Volume Measurements in Pediatric Patients With Dilated Cardiomyopathy. Circ Cardiovasc Imaging 10:
Margossian, Renee; Zak, Victor; Shillingford, Amanda J et al. (2017) The Effect of the Superior Cavopulmonary Anastomosis on Ventricular Remodeling in Infants with Single Ventricle. J Am Soc Echocardiogr 30:699-707.e1

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