The purpose of this project is to recruit an Assistant Professor into the San Diego Muscle Triglyceride Metabolism Core Center. The proposal is designed to integrate this individual into a worid-class group of investigators who have an excellent track record of NIH funding. While a number of our members study muscle function and structure, we do not have an expert in muscle metabolism. The need for such and individual has become obvious based on the clinical findings of intramuscular fat deposition in diabetes, secondary to rotator cuff tear, and in atrophied lumbar musculature. In order to understand these problems and develop effective treatments for them, a researcher with a background in muscle physiology and specialized training in muscle metabolism is necessary. In fact, we have found such an individual - Simon Schenk, Ph.D. Simon is a superbly-trained scientist with an outstanding record of scientific achievement and publication. We have already solicited letters of recommendation from well-know experts in the field including Gregory D. Cartee, Ph.D., University of Michigan, Edward F. Coyle, Ph.D., The University of Texas at Austin, Jacob (Jed) E. Friedman, Ph.D., University of Colorado, Jeffrey F. Horowitz, Ph.D., University of Michigan, and Jerrold M. Olefsky, M.D., University of California, San Diego. Without exception, these prominent scientist were effusive in their praise of Dr. Schenk professionally and personally. We are thus in the unique position of being able to recruit this postdoctoral fellow into our group and to mentor him regarding the Assistant Professor faculty position. Successful recruitment would create two new jobs that could be leveraged to create others, consistent with the objectives ofthe American Revitalization and Reinvestment Act (ARRA) passed by Congress in 2008.

Public Health Relevance

Many clinical problems result in intramuscular fat deposits. In the fields of sports medicine, orthopaedic surgery and endocrinology, intramuscular fat deposition is viewed as pathological and a sign of muscle functional loss. This proposal is desiged to recruit a muscle metabolic expert to the University of California, San Diego, where such pathologies can be studied and effective treatments developed.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Center Core Grants (P30)
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Study Section
Special Emphasis Panel (ZAR1-EHB-F (M2))
Program Officer
Tyree, Bernadette
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University of California San Diego
Schools of Medicine
La Jolla
United States
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O'Connor, Shawn M; Cheng, Elton J; Young, Kevin W et al. (2016) Quantification of sarcomere length distribution in whole muscle frozen sections. J Exp Biol 219:1432-6
LaBarge, Samuel A; Migdal, Christopher W; Buckner, Elisa H et al. (2016) p300 is not required for metabolic adaptation to endurance exercise training. FASEB J 30:1623-33
McCurdy, Carrie E; Schenk, Simon; Hetrick, Byron et al. (2016) Maternal obesity reduces oxidative capacity in fetal skeletal muscle of Japanese macaques. JCI Insight 1:e86612
LaBarge, Samuel; Migdal, Christopher; Schenk, Simon (2015) Is acetylation a metabolic rheostat that regulates skeletal muscle insulin action? Mol Cells 38:297-303
Philp, Andrew; Schenk, Simon; Perez-Schindler, Joaquin et al. (2015) Rapamycin does not prevent increases in myofibrillar or mitochondrial protein synthesis following endurance exercise. J Physiol 593:4275-84
White, Amanda T; LaBarge, Samuel A; McCurdy, Carrie E et al. (2015) Knockout of STAT3 in skeletal muscle does not prevent high-fat diet-induced insulin resistance. Mol Metab 4:569-75
Philp, Andrew; Rowland, Thomas; Perez-Schindler, Joaquin et al. (2014) Understanding the acetylome: translating targeted proteomics into meaningful physiology. Am J Physiol Cell Physiol 307:C763-73
McGlory, Chris; White, Amanda; Treins, Caroline et al. (2014) Application of the [?-32P] ATP kinase assay to study anabolic signaling in human skeletal muscle. J Appl Physiol (1985) 116:504-13
Meyer, Gretchen A; Schenk, Simon; Lieber, Richard L (2013) Role of the cytoskeleton in muscle transcriptional responses to altered use. Physiol Genomics 45:321-31
Philp, Andrew; Schenk, Simon (2013) Unraveling the complexities of SIRT1-mediated mitochondrial regulation in skeletal muscle. Exerc Sport Sci Rev 41:174-81

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