The goal of the Prostate Cancer Program is to reduce the burden of prostate cancer through dedicated and collaborative research.
The Specific Aims for the next project period are to 1) Identify molecular mechanisms driving the development and progression of prostate cancer and their interaction with germline genetic variations and environmental factors; 2) Identify critical functions of androgen receptor in prostate cancer development and progression and develop therapies that more effectively target this pathway while minimizing side effects; and 3) Improve prostate cancer treatment through better use of individual clinical and molecular characteristics to select or refine treatment and by the introduction of genetically based and other novel therapeutic strategies. The program has 87 members, representing seven DF/HCC institutions and 13 academic departments. In 2014 peer-reviewed grant funding attributed to the Program was $7 million in total costs from the NCI and $3.8 million from other sponsors. During the current funding period, Prostate Cancer Program members published 1,860 cancer-relevant papers. Of these 33% were inter-institutional, 26% were intra-programmatic, and 36% were inter-programmatic collaborations between two or more DF/HCC members. Overall, when counted once, 27% of DF/HCC publications were inter-programmatic collaborations.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA006516-55
Application #
9842693
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
55
Fiscal Year
2020
Total Cost
Indirect Cost
Name
Dana-Farber Cancer Institute
Department
Type
DUNS #
076580745
City
Boston
State
MA
Country
United States
Zip Code
02215
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Yao, Lina; Seaton, Sarah Craven; Ndousse-Fetter, Sula et al. (2018) A selective gut bacterial bile salt hydrolase alters host metabolism. Elife 7:
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Francini, Edoardo; Gray, Kathryn P; Xie, Wanling et al. (2018) Time of metastatic disease presentation and volume of disease are prognostic for metastatic hormone sensitive prostate cancer (mHSPC). Prostate 78:889-895
Hu, Yanhui; Vinayagam, Arunachalam; Nand, Ankita et al. (2018) Molecular Interaction Search Tool (MIST): an integrated resource for mining gene and protein interaction data. Nucleic Acids Res 46:D567-D574
Mohr, Stephanie E; Rudd, Kirstin; Hu, Yanhui et al. (2018) Zinc Detoxification: A Functional Genomics and Transcriptomics Analysis in Drosophila melanogaster Cultured Cells. G3 (Bethesda) 8:631-641
Odiaka, Emeka; Lounsbury, David W; Jalloh, Mohamed et al. (2018) Effective Project Management of a Pan-African Cancer Research Network: Men of African Descent and Carcinoma of the Prostate (MADCaP). J Glob Oncol :1-12

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