Abstract

Research over the preceding grant period has focused increasingly on the use of transgenic and mutant animals for our studies of neoplastic development. The Mutant Rodent Resource, a new shared service, will provide McArdle scientists with the capacity to manipulate the genome of experimental animals by providing ready access to the following technologies: . Generation of transgenic mice and rats by pronuclear microinjection . Generation of chimeric mice by microinjection of embryonic stem cells into host blastocysts . Cryopreservation of mouse sperm

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA007175-34
Application #
6268575
Study Section
Project Start
1998-05-22
Project End
1999-03-31
Budget Start
1997-10-01
Budget End
1998-09-30
Support Year
34
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715

  Publications

Thompson, Nancy E; Glaser, Bryan T; Foley, Katherine M et al. (2009) Minimal promoter systems reveal the importance of conserved residues in the B-finger of human transcription factor IIB. J Biol Chem 284:24754-66
Habig, Jeffrey W; Loeb, Daniel D (2006) Sequence identity of the direct repeats, DR1 and DR2, contributes to the discrimination between primer translocation and in situ priming during replication of the duck hepatitis B virus. J Mol Biol 364:32-43
Liu, Ning; Ji, Lin; Maguire, Megan L et al. (2004) cis-Acting sequences that contribute to the synthesis of relaxed-circular DNA of human hepatitis B virus. J Virol 78:642-9
Tessier, Charles R; Doyle, Glenn A; Clark, Brad A et al. (2004) Mammary tumor induction in transgenic mice expressing an RNA-binding protein. Cancer Res 64:209-14
Ostrow, Kristin M; Loeb, Daniel D (2004) Underrepresentation of the 3' region of the capsid pregenomic RNA of duck hepatitis B virus. J Virol 78:2179-86
Habig, Jeffrey W; Loeb, Daniel D (2003) Template switches during plus-strand DNA synthesis of duck hepatitis B virus are influenced by the base composition of the minus-strand terminal redundancy. J Virol 77:12412-20
Habig, Jeffrey W; Loeb, Daniel D (2003) The conformation of the 3' end of the minus-strand DNA makes multiple contributions to template switches during plus-strand DNA synthesis of duck hepatitis B virus. J Virol 77:12401-11
Bunger, Maureen K; Moran, Susan M; Glover, Edward et al. (2003) Resistance to 2,3,7,8-tetrachlorodibenzo-p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J Biol Chem 278:17767-74
Liu, Ning; Tian, Ru; Loeb, Daniel D (2003) Base pairing among three cis-acting sequences contributes to template switching during hepadnavirus reverse transcription. Proc Natl Acad Sci U S A 100:1984-9
Mueller-Hill, Karlyn; Loeb, Daniel D (2002) cis-Acting sequences 5E, M, and 3E interact to contribute to primer translocation and circularization during reverse transcription of avian hepadnavirus DNA. J Virol 76:4260-6

Showing the most recent 10 out of 79 publications