The Microchemistry and Proteomics Facility (MPF) supports laboratory and clinical research programs at MSKCC by (i) providing synthetic peptides and by (ii) performing mass spectrometric and amino acid sequence analyses of proteins and peptides, generally for the purpose of identification, relative quantitative analysis and post-translational modification (PTM) analysis. Synthetic molecules are made according to specifications provided by the investigator. Samples submitted for identification (either single proteins or mixtures), for PTM analysis or N-terminal sequencing are prepared by the lab requesting service. Information on chemistries and instrumentation, and expert advice on experimental approaches are provided by facility staff when needed. The goal of proteomics is to analyze changing levels, local concentrations and post-translational modifications of proteins in a cell, as well as to analyze higher-order networks of protein-protein interactions. Proteins and protein modifications are critical in the complex signaling pathways and regulatory processes underlying cell growth, division, differentiation, DNA repair, development, senescence, and in responses to bioactive agents, genetic alterations and disease. Dissection of multi-component protein complexes is therefore increasingly the focus of studies on molecular control mechanisms. Identification of unique components provides a powerful approach to the selective retrieval and identification of the companions. The impact that these services have provided, in facilitating research projects and enabling the timely progression of high priority research, can be recognized throughout the reports of the several research programs.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee G - Education (NCI)
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Sloan-Kettering Institute for Cancer Research
New York
United States
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Ricca, Jacob M; Oseledchyk, Anton; Walther, Tyler et al. (2018) Pre-existing Immunity to Oncolytic Virus Potentiates Its Immunotherapeutic Efficacy. Mol Ther 26:1008-1019
Nobel, Tamar B; Barbetta, Arianna; Hsu, Meier et al. (2018) Outcomes of Radiation-Associated Esophageal Squamous Cell Carcinoma: The MSKCC Experience. J Gastrointest Surg :
Lin, Jian-Xian; Yi, Brendan C; Yoon, Changhwan et al. (2018) Comparison of Outcomes for Elderly Gastric Cancer Patients at Least 80 Years of Age Following Gastrectomy in the United States and China. Ann Surg Oncol 25:3629-3638
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Lu, Jonathan E; Francis, Jasmine H; Dunkel, Ira J et al. (2018) Metastases and death rates after primary enucleation of unilateral retinoblastoma in the USA 2007-2017. Br J Ophthalmol :
Oikonomou, Evangelos K; Athanasopoulou, Sofia G; Kampaktsis, Polydoros N et al. (2018) Development and Validation of a Clinical Score for Cardiovascular Risk Stratification of Long-Term Childhood Cancer Survivors. Oncologist 23:965-973
Mo, Qianxing; Shen, Ronglai; Guo, Cui et al. (2018) A fully Bayesian latent variable model for integrative clustering analysis of multi-type omics data. Biostatistics 19:71-86
Deng, Gary; Giralt, Sergio; Chung, David J et al. (2018) Acupuncture for reduction of symptom burden in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation: a randomized sham-controlled trial. Support Care Cancer 26:657-665
Aloisi, Alessia; Sonoda, Yukio; Gardner, Ginger J et al. (2018) Prospective Comparative Study of Laparoscopic Narrow Band Imaging (NBI) Versus Standard Imaging in Gynecologic Oncology. Ann Surg Oncol 25:984-990

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