MSK is committed to the discovery and development of new tools and therapeutic agents for cancer detection, prevention, and treatment. The mission of the Organic Synthesis Core is to provide chemical synthesis services to Center members through a state-of-the art facility staffed by expert professional personnel in chemical synthesis. The Core operates at the interface of chemistry, biology, and medicine, and has the capability of supporting medicinal chemistry efforts to produce and evolve lead candidates and tool compounds in support of Center investigators. The work of the Core has greatly facilitated preclinical studies at the Center. The Core synthesizes novel molecules that are not readily available, by either following described procedures, or by developing new and more suitable methods of synthesis.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA008748-55
Application #
10084824
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
1997-01-20
Project End
2023-12-31
Budget Start
2021-01-01
Budget End
2021-12-31
Support Year
55
Fiscal Year
2021
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Rieth, Elizabeth F; Fischer, Gregory W; Afonso, Anoushka M (2018) Organization of Multidisciplinary Cancer Care for the Surgical Patient: Role of Anesthesiologists. Curr Anesthesiol Rep 8:368-374
Patel, Seema; Wang, Shiyang; Snuderl, Matija et al. (2018) Pre-treatment lymphopenia and indication of tumor-induced systemic immunosuppression in medulloblastoma. J Neurooncol 136:541-544
Mahajan, Sonia; Shaha, Ashok; Grewal, Ravinder K (2018) Incidental Detection of Medullary Thyroid Carcinoma by 68Ga-DOTATATE PET/CT in a Patient With Neuroendocrine Tumor Liver Metastases. Clin Nucl Med 43:136-138
Wertheimer, Tobias; Velardi, Enrico; Tsai, Jennifer et al. (2018) Production of BMP4 by endothelial cells is crucial for endogenous thymic regeneration. Sci Immunol 3:
Barbetta, Arianna; Faraz, Shahdabul; Shah, Pari et al. (2018) Quality of Endoscopy Reports for Esophageal Cancer Patients: Where Do We Stand? J Gastrointest Surg 22:778-784
Drilon, Alexander; Somwar, Romel; Mangatt, Biju P et al. (2018) Response to ERBB3-Directed Targeted Therapy in NRG1-Rearranged Cancers. Cancer Discov 8:686-695
Staffas, Anna; Burgos da Silva, Marina; Slingerland, Ann E et al. (2018) Nutritional Support from the Intestinal Microbiota Improves Hematopoietic Reconstitution after Bone Marrow Transplantation in Mice. Cell Host Microbe 23:447-457.e4
Krebs, Simone; Ahad, Afruja; Carter, Lukas M et al. (2018) Antibody with Infinite Affinity for In Vivo Tracking of Genetically Engineered Lymphocytes. J Nucl Med 59:1894-1900
Cruz, C; Castroviejo-Bermejo, M; Gutiérrez-Enríquez, S et al. (2018) RAD51 foci as a functional biomarker of homologous recombination repair and PARP inhibitor resistance in germline BRCA-mutated breast cancer. Ann Oncol 29:1203-1210
Owosho, Adepitan A; Estilo, Cherry L; Huryn, Joseph M et al. (2018) A Clinicopathologic Study of Head and Neck Malignant Peripheral Nerve Sheath Tumors. Head Neck Pathol 12:151-159

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