MSK is committed to the discovery and development of new tools and therapeutic agents for cancer detection, prevention, and treatment. The mission of the Organic Synthesis Core is to provide chemical synthesis services to Center members through a state-of-the art facility staffed by expert professional personnel in chemical synthesis. The Core operates at the interface of chemistry, biology, and medicine, and has the capability of supporting medicinal chemistry efforts to produce and evolve lead candidates and tool compounds in support of Center investigators. The work of the Core has greatly facilitated preclinical studies at the Center. The Core synthesizes novel molecules that are not readily available, by either following described procedures, or by developing new and more suitable methods of synthesis.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee I - Transistion to Independence (NCI)
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Sloan-Kettering Institute for Cancer Research
New York
United States
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Chowell, Diego; Morris, Luc G T; Grigg, Claud M et al. (2018) Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy. Science 359:582-587
Morgani, Sophie M; Metzger, Jakob J; Nichols, Jennifer et al. (2018) Micropattern differentiation of mouse pluripotent stem cells recapitulates embryo regionalized cell fate patterning. Elife 7:
Senders, Max L; Que, Xuchu; Cho, Young Seok et al. (2018) PET/MR Imaging of Malondialdehyde-Acetaldehyde Epitopes With a Human Antibody Detects Clinically Relevant Atherothrombosis. J Am Coll Cardiol 71:321-335
Fang, Jing; Muto, Tomoya; Kleppe, Maria et al. (2018) TRAF6 Mediates Basal Activation of NF-?B Necessary for Hematopoietic Stem Cell Homeostasis. Cell Rep 22:1250-1262
Desrichard, Alexis; Kuo, Fengshen; Chowell, Diego et al. (2018) Tobacco Smoking-Associated Alterations in the Immune Microenvironment of Squamous Cell Carcinomas. J Natl Cancer Inst :
Mariathasan, Sanjeev; Turley, Shannon J; Nickles, Dorothee et al. (2018) TGF? attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells. Nature 554:544-548
Ghaznavi, Sana A; Ganly, Ian; Shaha, Ashok R et al. (2018) Using the American Thyroid Association Risk-Stratification System to Refine and Individualize the American Joint Committee on Cancer Eighth Edition Disease-Specific Survival Estimates in Differentiated Thyroid Cancer. Thyroid 28:1293-1300
Hernandez, Jonathan M; Beylergil, Volkan; Goldman, Debra A et al. (2018) Post-Treatment/Pre-operative PET Response Is Not an Independent Predictor of Outcomes for Patients With Gastric and GEJ Adenocarcinoma. Ann Surg 267:898-904
Juluru, Krishna; Elnajjar, Pierre; Shih, Hao-Hsin et al. (2018) An Informatics Approach to Facilitate Clinical Management of Patients With Retrievable Inferior Vena Cava Filters. AJR Am J Roentgenol 211:W178-W184
Li, Guang; Sun, August; Nie, Xingyu et al. (2018) Introduction of a pseudo demons force to enhance deformation range for robust reconstruction of super-resolution time-resolved 4DMRI. Med Phys 45:5197-5207

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