05 CANCER CHEMOPREVENTION (CCP) PROGRAM ABSTRACT The UAB Cancer Center Chemoprevention Program was established to identify novel chemopreventive agents capable of preventing cancer, to determine the ability of naturally occurring and synthetic chemicals to prevent or delay carcinogenesis, to determine their mechanisms of action and identify biomarkers, and to perform early phase chemoprevention trials evaluating novel chemopreventive agents. The focus of the Program is directed toward synthetic retinoids, non-steroidal anti-inflammatory drugs, and phytochemicals. However, the scope of the program and depth of expertise have been expanded by strategic recruitment and a mentoring program. Furthermore, transdisciplinary research is nurtured through focused working groups. This program is co- directed by Dr. Craig A. Elmets (Professor and Chair, Department of Dermatology and Director of the UAB Skin Diseases Research Center) and Dr. Clinton J. Grubbs (Professor, Department of Surgery and Director of the Chemoprevention Center). Currently, the program is comprised of 18 members from 10 departments and 5 schools. This program has $4,187,741 in annual direct cost funding, of which 76% is derived from the NCI. In addition to the traditional utilization of inter-programmatic teams and intra-programmatic collaborations, the capabilities of the program are greatly expanded by established extramural agreements: (1) Dr. Grubbs directs Task Order from the NCI PREVENT program which awards contracts to investigators both at UAB and other institutions, and (2) Dr. Elmets participates in an NCI-funded consortium of early phase human chemoprevention trials led by the University of Wisconsin. Over the past four years, the program has produced 206 publications, of which 35% % were intra-programmatic, 28%% were inter-programmatic, and 34% were inter-institutional. A vibrant communications component that includes a seminar series with lecturers from inside and outside the University supports collaborative research among program investigators. Major completed studies at UAB have moved chemopreventive agents from various classes (including rexinoids, cyclooxygenase inhibitors, and dietary polyphenols) to clinical trials during the last few years.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
He, Min
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
United States
Zip Code
Carson, Tiffany L; Wang, Fuchenchu; Cui, Xiangqin et al. (2018) Associations Between Race, Perceived Psychological Stress, and the Gut Microbiota in a Sample of Generally Healthy Black and White Women: A Pilot Study on the Role of Race and Perceived Psychological Stress. Psychosom Med 80:640-648
Williams, Adele P; Waters, Alicia M; Stewart, Jerry E et al. (2018) A novel retinoid X receptor agonist, UAB30, inhibits rhabdomyosarcoma cells in vitro. J Surg Res 228:54-62
Frugé, Andrew D; Cases, Mallory G; Howell, Carrie R et al. (2018) Fingernail and toenail clippings as a non-invasive measure of chronic cortisol levels in adult cancer survivors. Cancer Causes Control 29:185-191
McCaw, Tyler R; Randall, Troy D; Arend, Rebecca C (2018) Overcoming immune suppression with epigenetic modification in ovarian cancer. Transl Res :
Geng, Mengxin; Austin, Frank; Shin, Ronald et al. (2018) Covalent Structure and Bioactivity of the Type AII Lantibiotic Salivaricin A2. Appl Environ Microbiol 84:
Samykutty, Abhilash; Grizzle, William E; Fouts, Benjamin L et al. (2018) Optoacoustic imaging identifies ovarian cancer using a microenvironment targeted theranostic wormhole mesoporous silica nanoparticle. Biomaterials 182:114-126
Friedman, Gregory K; Bernstock, Joshua D; Chen, Dongquan et al. (2018) Enhanced Sensitivity of Patient-Derived Pediatric High-Grade Brain Tumor Xenografts to Oncolytic HSV-1 Virotherapy Correlates with Nectin-1 Expression. Sci Rep 8:13930
Powell, T Clark; Dilley, Sarah E; Bae, Sejong et al. (2018) The Impact of Racial, Geographic, and Socioeconomic Risk Factors on the Development of Advanced-Stage Cervical Cancer. J Low Genit Tract Dis 22:269-273
Kasten, Benjamin B; Oliver, Patsy G; Kim, Harrison et al. (2018) 212Pb-Labeled Antibody 225.28 Targeted to Chondroitin Sulfate Proteoglycan 4 for Triple-Negative Breast Cancer Therapy in Mouse Models. Int J Mol Sci 19:
Subramaniam, Akila; Blanchard, Christina T; Erickson, Britt K et al. (2018) Feasibility of Complete Salpingectomy Compared With Standard Postpartum Tubal Ligation at Cesarean Delivery: A Randomized Controlled Trial. Obstet Gynecol 132:20-27

Showing the most recent 10 out of 747 publications