Abstract

The Protocol Review and Monitoring System consists of the Protocol Review and Monitoring Committee (PRMC) and its subcommittee, the Quality Assurance Committee (QA). The PRMC meets biweekly to review newly submitted interventional protocols. The PRMC has three functions: 1. Review protocols for scientific merit and prioritization to assure efficient use of HICCC resources;2. Monitor accrual and close trials that fail to demonstrate activity;3. Review and act on reports from the QA Committee. The PRMC also provides support to investigators regarding design of informed consents. The QA Committee conducts periodic audits on investigator initiated trials and reviews data audits conducted by cooperative groups and by trial sponsors/The QA also interacts with the IRB and with Theradex or other independent auditing groups to assure that there is periodic monitoring of the conduct of institutional trials at HICCC. The projected operating budget of the PRMS is $318,332, of which we are requesting $151,915 from the CCSG.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA013696-36
Application #
7862553
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2009-07-01
Budget End
2010-06-30
Support Year
36
Fiscal Year
2009
Total Cost
$219,418
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
DUNS #
621889815
City
New York
State
NY
Country
United States
Zip Code
10032

  Publications

Billing, David; Horiguchi, Michiko; Wu-Baer, Foon et al. (2018) The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection. Mol Cell 72:127-139.e8
Connors, Thomas J; Baird, J Scott; Yopes, Margot C et al. (2018) Developmental Regulation of Effector and Resident Memory T Cell Generation during Pediatric Viral Respiratory Tract Infection. J Immunol 201:432-439
Brescia, Paola; Schneider, Christof; Holmes, Antony B et al. (2018) MEF2B Instructs Germinal Center Development and Acts as an Oncogene in B Cell Lymphomagenesis. Cancer Cell 34:453-465.e9
Wu, Hui-Chen; Do, Catherine; Andrulis, Irene L et al. (2018) Breast cancer family history and allele-specific DNA methylation in the legacy girls study. Epigenetics 13:240-250
Sitko, Austen A; Kuwajima, Takaaki; Mason, Carol A (2018) Eye-specific segregation and differential fasciculation of developing retinal ganglion cell axons in the mouse visual pathway. J Comp Neurol 526:1077-1096
Tzoneva, Gannie; Dieck, Chelsea L; Oshima, Koichi et al. (2018) Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia. Nature 553:511-514
Wang, Gang; Biswas, Anup K; Ma, Wanchao et al. (2018) Metastatic cancers promote cachexia through ZIP14 upregulation in skeletal muscle. Nat Med 24:770-781
Chen, Yen-Hua; Kratchmarov, Radomir; Lin, Wen-Hsuan W et al. (2018) Asymmetric PI3K Activity in Lymphocytes Organized by a PI3K-Mediated Polarity Pathway. Cell Rep 22:860-868
Cho, Galaxy Y; Schaefer, Kellie A; Bassuk, Alexander G et al. (2018) CRISPR GENOME SURGERY IN THE RETINA IN LIGHT OF OFF-TARGETING. Retina 38:1443-1455
Zyablitskaya, Mariya; Munteanu, E Laura; Nagasaki, Takayuki et al. (2018) Second Harmonic Generation Signals in Rabbit Sclera As a Tool for Evaluation of Therapeutic Tissue Cross-linking (TXL) for Myopia. J Vis Exp :

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