A primary focus of the Koch Institute?s research program is to understand the molecular and cellular changes associated with cancer development and progression and develop new treatments and diagnostic approaches. The Microscopy Core provides state-of-the-art imaging in both cells and in the in vivo setting, which are essential tools for these studies. In the current period, the capabilities of this Core have been expanded and enhanced. This includes: moving into a larger, custom-designed space in the new Koch Institute building; the acquisition of new instrumentation; and the recruitment of a world-renowned expert in intravital imaging, Jeffrey Wyckoff, to the Core?s staff. Notably, in the same period, 78% of Center Members used the Microscopy Core, including investigators from all four Programs. Thus, this Shared Resource is essential to the success of the Koch Institute mission. In the upcoming period, this Core will continue to offer a wide range of state-of-the-art imaging technologies to support the research programs of Center Members. To support its expanded staff, the requested budget for Year 44 is increased 45%, compared to the requested and recommended budget in Year 39. The CCSG budgets of other Koch Institute Cores have been reduced or eliminated to more than offset the proposed increase in this, and other, Cores.
| Rothenberg, Daniel A; Taliaferro, J Matthew; Huber, Sabrina M et al. (2018) A Proteomics Approach to Profiling the Temporal Translational Response to Stress and Growth. iScience 9:367-381 |
| Kimmerling, Robert J; Prakadan, Sanjay M; Gupta, Alejandro J et al. (2018) Linking single-cell measurements of mass, growth rate, and gene expression. Genome Biol 19:207 |
| Tang, Li; Zheng, Yiran; Melo, Mariane Bandeira et al. (2018) Enhancing T cell therapy through TCR-signaling-responsive nanoparticle drug delivery. Nat Biotechnol 36:707-716 |
| Holec, Patrick V; Berleant, Joseph; Bathe, Mark et al. (2018) A Bayesian framework for high-throughput T cell receptor pairing. Bioinformatics : |
| Wong, Madeline Y; Doan, Ngoc Duc; DiChiara, Andrew S et al. (2018) A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production. Biochemistry 57:2814-2827 |
| Danai, Laura V; Babic, Ana; Rosenthal, Michael H et al. (2018) Altered exocrine function can drive adipose wasting in early pancreatic cancer. Nature 558:600-604 |
| Dubbury, Sara J; Boutz, Paul L; Sharp, Phillip A (2018) CDK12 regulates DNA repair genes by suppressing intronic polyadenylation. Nature 564:141-145 |
| Tokatlian, Talar; Kulp, Daniel W; Mutafyan, Andrew A et al. (2018) Enhancing Humoral Responses Against HIV Envelope Trimers via Nanoparticle Delivery with Stabilized Synthetic Liposomes. Sci Rep 8:16527 |
| Crowell, Laura E; Lu, Amos E; Love, Kerry R et al. (2018) On-demand manufacturing of clinical-quality biopharmaceuticals. Nat Biotechnol : |
| Lo, Justin H; Hao, Liangliang; Muzumdar, Mandar D et al. (2018) iRGD-guided Tumor-penetrating Nanocomplexes for Therapeutic siRNA Delivery to Pancreatic Cancer. Mol Cancer Ther 17:2377-2388 |
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