The Translational Pathology Core provides normal and tumor tissue specimens necessary for the laboratory-based, epidemiologic and clinical studies being conducted by USC Norris Comprehensive Cancer Center (KiCCC) investigators. As cancer research increasingly utilizes human tumor specimens, the need for this service has escalated accordingly. It is now indispensable for many NCCC investigators. Tissue specimens have been provided to 24 NCCC members with active peer-reviewed research funding. The Core is organized into three arms, each with distinct but related functions;the Adult Tissue Arm (ATA) supervised by Dr. Andrew Sherrod, supplies fresh/frozen adult normal and tumor tissue and fluid specimens, the Pediatric Tissue Arm (PTA) supervised by Dr. Hiroyuki Shimada, provides pediatric tumor tissue specimens, and the Population Based Tissue Arm (PBTA) supervised by Dr. Wendy Cozen, provides population-based, fixed tissue specimens primarily for epidemiologic studies. Overall, coordination of these services is under the direction of Dr. Sue Ellen Martin. By using this Core, NCCC investigators were able to identify molecular markers associated with tumor recurrence in 250 patients with stage 2 and 3 colon cancer and 103 stage 1-3 gastric cancer, collaborated with the Broad Institute on the 8q24 pathway getting 100 fresh tissues leading to a Nature Genetics publication, publish a molecular classification of childhood rhabdomyosarcoma based on genotypic and phenotypic determinants that distinguish two major prognostic groups, and identified an ethnic-specific tumor marker for prostate cancer.

Public Health Relevance

Normal and diseased tissues which are fresh/frozen or obtained from paraffin blocks are indispensible for translational cancer research. This Core with these arms provides fresh/frozen tissue from pediatric and adult subjects. It also has a unique ability to provide population-based fixed specimens for epidemiological studies.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014089-39
Application #
8589354
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
39
Fiscal Year
2014
Total Cost
$631,729
Indirect Cost
$229,876
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Zhao, Yi; Wu, Kaijin; Wu, Yongfeng et al. (2018) Characterization of Imatinib Resistant CML Leukemic Stem/Initiating Cells and Their Sensitivity to CBP/Catenin Antagonists. Curr Mol Pharmacol 11:113-121
Kahn, Michael (2018) Wnt Signaling in Stem Cells and Cancer Stem Cells: A Tale of Two Coactivators. Prog Mol Biol Transl Sci 153:209-244
Park, Sungshim L; Patel, Yesha M; Loo, Lenora W M et al. (2018) Association of internal smoking dose with blood DNA methylation in three racial/ethnic populations. Clin Epigenetics 10:110
Liu, Jie; Liang, Gangning; Siegmund, Kimberly D et al. (2018) Data integration by multi-tuning parameter elastic net regression. BMC Bioinformatics 19:369
McDonnell, Kevin J; Chemler, Joseph A; Bartels, Phillip L et al. (2018) A human MUTYH variant linking colonic polyposis to redox degradation of the [4Fe4S]2+ cluster. Nat Chem 10:873-880
Schirripa, Marta; Zhang, Wu; Yang, Dongyun et al. (2018) NOS2 polymorphisms in prediction of benefit from first-line chemotherapy in metastatic colorectal cancer patients. PLoS One 13:e0193640
Ryser, Marc D; Min, Byung-Hoon; Siegmund, Kimberly D et al. (2018) Spatial mutation patterns as markers of early colorectal tumor cell mobility. Proc Natl Acad Sci U S A 115:5774-5779
Rhie, Suhn Kyong; Schreiner, Shannon; Farnham, Peggy J (2018) Defining Regulatory Elements in the Human Genome Using Nucleosome Occupancy and Methylome Sequencing (NOMe-Seq). Methods Mol Biol 1766:209-229
Zhou, Beiyun; Flodby, Per; Luo, Jiao et al. (2018) Claudin-18-mediated YAP activity regulates lung stem and progenitor cell homeostasis and tumorigenesis. J Clin Invest 128:970-984
Nguyen, Lisa; Wang, Zheng; Chowdhury, Adnan Y et al. (2018) Functional compensation between hematopoietic stem cell clones in vivo. EMBO Rep 19:

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