The aims of the USC Norris Cancer Control Research Program are to elucidate the etiology of cancer risk behaviors in the general population and develop primary prevention interventions that modify cancer risk behavior and enhance secondary prevention, clinical care, and survivorship.
These aims serve the overarching goal of reducing and eliminating cancer health disparities among the populations represented in the USC Norris catchment area, with implications for other populations globally. The Program's goals align with the USC Norris strategic plan by: a) developing and testing new interventions that impact the cancer burden; b) applying cutting-edge technology and methodology to assess exposures and disseminate interventions; and c) spanning the continuum of care from primary prevention to survivorship. A hallmark of this Program has been the application of innovative theory and methodology to develop integrated lines of research on cancer risk behaviors and preventive interventions. Given that the diverse, vulnerable, and disadvantaged members of the catchment area reached by the Program's work also reflect the disparities seen at the US population level and the Program makes significant strides in addressing the mission of NCI's efforts in cancer control and population sciences. Recent achievements of the Program, which is led by two internationally-recognized experts, Mary Ann Pentz (primary prevention) and Anna Wu (secondary prevention and survivorship), include 1) understanding mental health comorbidities with tobacco use to inform more tailored smoking cessation programs for vulnerable smokers who have been unable to quit by other means; 2) promoting cultural values and decreasing perceived cultural discrimination as means to improve tobacco prevention and control efforts with Hispanic youth and adults; and 3) utilizing executive function and mindfulness skills training in primary prevention programs that target diet, physical inactivity, and other cancer risk behaviors in youth and applying such interventions to cancer patients, caregivers, and families to improve treatment outcomes. The 30 members represent five schools and 13 departments at USC, and have $15M in peer-reviewed funding (direct costs), 33% of which is from NCI, 27% from other NIH sources, and 33% from other peer-reviewed funding sources. The Program is highly productive with 756 publications of which 17% are inter-programmatic, 23% intra-programmatic and 53% inter-institutional.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014089-44
Application #
9607945
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2018-12-01
Budget End
2019-11-30
Support Year
44
Fiscal Year
2019
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Basso, Virginia; Garcia, Angie; Tran, Dat Q et al. (2018) Fungicidal Potency and Mechanisms of ?-Defensins against Multidrug-Resistant Candida Species. Antimicrob Agents Chemother 62:
Neumeyer, Sonja; Banbury, Barbara L; Arndt, Volker et al. (2018) Mendelian randomisation study of age at menarche and age at menopause and the risk of colorectal cancer. Br J Cancer 118:1639-1647
Ning, Y; Zhang, W; Hanna, D L et al. (2018) Clinical relevance of EMT and stem-like gene expression in circulating tumor cells of metastatic colorectal cancer patients. Pharmacogenomics J 18:29-34
Austria, Theresa; Marion, Christine; Yu, Vanessa et al. (2018) Mechanism of cytokinesis failure in ovarian cystadenomas with defective BRCA1 and P53 pathways. Int J Cancer 143:2932-2942
Zhang, Junjie; Zhao, Jun; Xu, Simin et al. (2018) Species-Specific Deamidation of cGAS by Herpes Simplex Virus UL37 Protein Facilitates Viral Replication. Cell Host Microbe 24:234-248.e5
Eriguchi, Yoshihiro; Nakamura, Kiminori; Yokoi, Yuki et al. (2018) Essential role of IFN-? in T cell-associated intestinal inflammation. JCI Insight 3:
Battaglin, Francesca; Naseem, Madiha; Puccini, Alberto et al. (2018) Molecular biomarkers in gastro-esophageal cancer: recent developments, current trends and future directions. Cancer Cell Int 18:99
Cobo, Eduardo R; Holani, Ravi; Moreau, France et al. (2018) Entamoeba histolytica Alters ileal Paneth Cell Functions in Intact and Muc2 Mucin Deficiency. Infect Immun :
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu et al. (2018) Gene Polymorphisms in the CCL5/CCR5 Pathway as a Genetic Biomarker for Outcome and Hand-Foot Skin Reaction in Metastatic Colorectal Cancer Patients Treated With Regorafenib. Clin Colorectal Cancer 17:e395-e414
Thomas, Nancy E; Edmiston, Sharon N; Orlow, Irene et al. (2018) Inherited Genetic Variants Associated with Melanoma BRAF/NRAS Subtypes. J Invest Dermatol 138:2398-2404

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