The Cell and Tissue Imaging Core provides advanced cell and tissue imaging technology, services, and scientific consultation. The Core facilitates scientific collaboration and advances the ability of USC Norris members to conduct innovative cancer research. Since its founding 15 years ago, the Cell and Tissue Imaging Core has been continuously approved and funded by the NCI CCSG. The facility has been ably led by the founding Director, Dr. David Hinton, and supervised by Technical Director, Ernesto Barron, both of whom have over 30 years of experience in the field of microscopy. In 2014, Dr. Scott Fraser, an internationally recognized innovator in imaging technology, was recruited to USC from Caltech. With the goal of providing national leadership in imaging technology through the facility, Dr. Fraser joined Dr. Hinton as Co-Director effective January 2015. The Cell and Tissue Imaging Core makes it possible for Cancer Center members to easily access a wide range of sophisticated imaging equipment and services, including laser scanning confocal/multiphoton microscopy, live cell spinning disk confocal imaging, transmission electron microscopy (TEM), scanning electron microscopy (SEM), digital light and fluorescence microscopy, fluorescence and bright field laser capture microdissection, thin sectioning, cryo-sectioning and embedding techniques, and computer aided graphics. In its effort to provide state-of-the-art technology, the Core is adding new instrumentation: a STORM super-resolution single-molecule imaging fluorescence microscope, a Two-Photon SPIM light sheet imager, a Flip Trap imaging scope, and a novel Hyperspectral Phasor Imaging (HPI) instrument. As a part of its mission to help members learn how Core resources can advance their research, the Core has an active education and training program through which it advises and instructs USC Norris investigators in novel methodologies and protocols to enhance their cell and tissue imaging capability. In FY 2013-2014, the Core was used by 36 Cancer Center members from six USC Norris Research Programs, which reflects both the quality of the service and the value of continued education and training efforts. In the fall of 2015, the Core will relocate to renovated space in USC Norris Topping Tower. Closer proximity to the majority of users and increased overall visibility should result in increased usage in the next project period.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014089-45
Application #
9838167
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2019-12-01
Budget End
2020-11-30
Support Year
45
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Southern California
Department
Type
DUNS #
072933393
City
Los Angeles
State
CA
Country
United States
Zip Code
90089
Suenaga, Mitsukuni; Schirripa, Marta; Cao, Shu et al. (2018) Potential role of PIN1 genotypes in predicting benefit from oxaliplatin-based and irinotecan-based treatment in patients with metastatic colorectal cancer. Pharmacogenomics J 18:623-632
Singh, Hardeep P; Wang, Sijia; Stachelek, Kevin et al. (2018) Developmental stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors. Proc Natl Acad Sci U S A 115:E9391-E9400
Tsai, Yuan-Li; Ha, Dat P; Zhao, He et al. (2018) Endoplasmic reticulum stress activates SRC, relocating chaperones to the cell surface where GRP78/CD109 blocks TGF-? signaling. Proc Natl Acad Sci U S A 115:E4245-E4254
Rodrigues, Luana L S; Morgado, Mariza G; Sahasrabuddhe, Vikrant V et al. (2018) Cervico-vaginal self-collection in HIV-infected and uninfected women from Tapajós region, Amazon, Brazil: High acceptability, hrHPV diversity and risk factors. Gynecol Oncol 151:102-110
Valentin-Torres, Alice; Savarin, Carine; Barnett, Joslyn et al. (2018) Blockade of sustained tumor necrosis factor in a transgenic model of progressive autoimmune encephalomyelitis limits oligodendrocyte apoptosis and promotes oligodendrocyte maturation. J Neuroinflammation 15:121
Ricker, Charité N; Koff, Rachel B; Qu, Chenxu et al. (2018) Patient communication of cancer genetic test results in a diverse population. Transl Behav Med 8:85-94
Jayne, Jordanna G; Bensman, Timothy J; Schaal, Justin B et al. (2018) Rhesus ?-Defensin-1 Attenuates Endotoxin-induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment. Am J Respir Cell Mol Biol 58:310-319
Tobin, Jessica; Miller, Kimberly A; Baezconde-Garbanati, Lourdes et al. (2018) Acculturation, Mental Health, and Quality of Life among Hispanic Childhood Cancer Survivors: A Latent Class Analysis. Ethn Dis 28:55-60
Harris, Holly R; Babic, Ana; Webb, Penelope M et al. (2018) Polycystic Ovary Syndrome, Oligomenorrhea, and Risk of Ovarian Cancer Histotypes: Evidence from the Ovarian Cancer Association Consortium. Cancer Epidemiol Biomarkers Prev 27:174-182
Lee, Brian H; Stallcup, Michael R (2018) Different chromatin and DNA sequence characteristics define glucocorticoid receptor binding sites that are blocked or not blocked by coregulator Hic-5. PLoS One 13:e0196965

Showing the most recent 10 out of 842 publications