Approximately 50% of all cancer patients are treated with radiotherapy, and of those, a significant percentage are treated with curative intent. Given the widespread use of this modality, it is imperative that means be established to increase the likelihood that local tumor control can be achieved, while preserving the integrity of normal tissues. This common paradigm fits this program well, but it is now being addressed with modern radiotherapy practices in the context of cutting-edge imaging and translational sciences.
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