Co-Leaders: Paul F. Lambert and Shannon Kenney PROJECT SUMMARY/ABSTRACT Human tumor viruses are causally associated with over 15% of all human cancers and are likely to contribute to additional cancers. The mission of the Human Cancer Virology (VR) Program is to advance the understanding, prevention, and treatment of virus-associated cancers and other cancers through basic research. The program has 14 highly collaborative members who span 7 departments and 3 schools on the UW campus; 4 are MDs who run research labs and practice in the Dept. of Medicine or Surgery, bringing valuable clinical perspectives to the program. The VR program members study 6 of the 7 established human tumor viruses as well as HIV/SIV. Since the beginning of the current funding period, the VR members have published 196 publications (including numerous papers in PNAS, JCI, Cell Host Microbe, PLOS Pathogens, and other high impact journals), or on average 16 publications per member over the current funding period. Of these publications, ~21.5% were inter-programmatic collaborations and ~11% were intra-programmatic collaborations. In the year 2016 alone, nearly 46% of publications were collaborative with other institutions. The 14 VR Program members are well funded with $4.46M Direct peer-reviewed awards (>48% from NCI) and additional funding sources (e.g. Morgridge Institute for Paul Ahlquist, UW2020 Program for Nathan Sherer). In the last funding cycle, members of the VR program renewed the long-standing NCI program project grant on tumor viruses and played a central role in obtaining a new SPORE in head and neck cancer.
The aims of the UWCCC Human Cancer Virology Program (VR), which span all aspects of the UWCCC Strategic Operating Plan, are to: 1) elucidate the pathways by which diverse tumor viruses infect, replicate, interact with their hosts, and maintain their presence through the years to decades typically associated with tumor development and progression; 2) determine the mechanisms by which tumor viruses promote tumor induction and maintenance, including identifying viral and host genes essential to the continuing survival of tumor cells; and 3) define molecular changes and diagnostic/prognostic biomarkers of virally induced infections and neoplasia and use these insights to develop novel, improved approaches to prevent and treat tumor virus infection, replication, tumor induction and maintenance.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014520-46
Application #
9923037
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
2020-04-01
Budget End
2021-03-31
Support Year
46
Fiscal Year
2020
Total Cost
Indirect Cost
Name
University of Wisconsin Madison
Department
Type
DUNS #
161202122
City
Madison
State
WI
Country
United States
Zip Code
53715
Fu, Anqi; Oberholtzer, Sydney M; Bagheri-Fam, Stefan et al. (2018) Dynamic expression patterns of Irx3 and Irx5 during germline nest breakdown and primordial follicle formation promote follicle survival in mouse ovaries. PLoS Genet 14:e1007488
Ni, Dalong; Jiang, Dawei; Kutyreff, Christopher J et al. (2018) Molybdenum-based nanoclusters act as antioxidants and ameliorate acute kidney injury in mice. Nat Commun 9:5421
Huynh, Mailee; Pak, Chorom; Markovina, Stephanie et al. (2018) Hyaluronan and proteoglycan link protein 1 (HAPLN1) activates bortezomib-resistant NF-?B activity and increases drug resistance in multiple myeloma. J Biol Chem 293:2452-2465
Wu, Yirong; Fan, Jun; Peissig, Peggy et al. (2018) Quantifying predictive capability of electronic health records for the most harmful breast cancer. Proc SPIE Int Soc Opt Eng 10577:
Net, Jose M; Whitman, Gary J; Morris, Elizabteh et al. (2018) Relationships Between Human-Extracted MRI Tumor Phenotypes of Breast Cancer and Clinical Prognostic Indicators Including Receptor Status and Molecular Subtype. Curr Probl Diagn Radiol :
Jiang, Dawei; Ge, Zhilei; Im, Hyung-Jun et al. (2018) DNA origami nanostructures can exhibit preferential renal uptake and alleviate acute kidney injury. Nat Biomed Eng 2:865-877
Seok, Seung-Hyeon; Ma, Zhi-Xiong; Feltenberger, John B et al. (2018) Trace derivatives of kynurenine potently activate the aryl hydrocarbon receptor (AHR). J Biol Chem 293:1994-2005
Farrell, Emily; Armstrong, Annie E; Grimes, Adrian C et al. (2018) Transcriptome Analysis of Cardiac Hypertrophic Growth in MYBPC3-Null Mice Suggests Early Responders in Hypertrophic Remodeling. Front Physiol 9:1442
Ni, Dalong; Ferreira, Carolina A; Barnhart, Todd E et al. (2018) Magnetic Targeting of Nanotheranostics Enhances Cerenkov Radiation-Induced Photodynamic Therapy. J Am Chem Soc 140:14971-14979
Chang, Julie E; Carmichael, Lakeesha L; Kim, KyungMann et al. (2018) VcR-CVAD Induction Chemotherapy Followed by Maintenance Rituximab Produces Durable Remissions in Mantle Cell Lymphoma: A Wisconsin Oncology Network Study. Clin Lymphoma Myeloma Leuk 18:e61-e67

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