The Genomics Core Facility (GCF) was created in 2006 by combining two existing institutional cores - the UCCRC-supported DNA Sequencing and Genotyping Facility and the Functional Genomics Facility - with the genomics-related bioinformatics services previously provided by the developing Biomedical Informatics Facility. These resources have become so integral to cutting-edge research in the biological sciences that essentially every laboratory-based investigator in the UCCRC will access them on a regular basis. While these facilities have previously operated independently, their functions overlap in complementary and necessary ways. The merger into a single, integrated Core, a task that will be completed with co-localization in dedicated space in the Knapp Center for Biomedical Discovery (KCBD; a new building which will be completed in 2008), will result in significant benefit to investigators. Over 82 peer-reviewed UCCRC investigators across all six Scientific Programs routinely use the combined Functional Genomics and DNA Sequencing and Genotyping Facilities, representing 44% of Facility usage. The Facility provides state-of-the-art microarray, DNA sequencing, and genotyping platforms with specialized databases for storing, managing, and manipulating both clinical information (phenotypes) and diverse types of genetic and genomic data (genotypes). Expert assistance in the detection technologies, as well as adapting the resulting data to modern database solutions using high-speed specialized hardware and sophisticated commercial and academic software tailored for genomics and bioinformatics research will provide UCCRC investigators who use the GCF the highest standards of data acquisition, protection, confidentiality, and HIPAA compliance currently available to academic researchers. The GCF is aimed towards biomedical researchers who are generally unfamiliar with whole genome and bioinformatics approaches, as well as experts seeking more sophisticated hardware, software, programming, or database solutions, or seeking to facilitate interdisciplinary collaborations. Major goals of the GCF are to provide investigators with scientific and technical staff who can assist with or collaborate on individual projects, provide an educational program that allows investigators to seek their own levels of expertise and sophistication in a given application, and raise awareness of new directions and major discoveries in the areas of genomics and bioinformatics.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA014599-36
Application #
8244549
Study Section
Special Emphasis Panel (ZCA1)
Project Start
Project End
Budget Start
2011-04-01
Budget End
2012-03-31
Support Year
36
Fiscal Year
2011
Total Cost
$433,570
Indirect Cost
Name
University of Chicago
Department
Type
DUNS #
005421136
City
Chicago
State
IL
Country
United States
Zip Code
60637
Liu, Hongtao; Zha, Yuanyuan; Choudhury, Noura et al. (2018) WT1 peptide vaccine in Montanide in contrast to poly ICLC, is able to induce WT1-specific immune response with TCR clonal enrichment in myeloid leukemia. Exp Hematol Oncol 7:1
Nageeb, Shaheen; Vu, Milkie; Malik, Sana et al. (2018) Adapting a religious health fatalism measure for use in Muslim populations. PLoS One 13:e0206898
Ferreira, Caroline M; Williams, Jesse W; Tong, Jiankun et al. (2018) Allergen Exposure in Lymphopenic Fas-Deficient Mice Results in Persistent Eosinophilia Due to Defects in Resolution of Inflammation. Front Immunol 9:2395
Luke, Jason J; Lemons, Jeffrey M; Karrison, Theodore G et al. (2018) Safety and Clinical Activity of Pembrolizumab and Multisite Stereotactic Body Radiotherapy in Patients With Advanced Solid Tumors. J Clin Oncol 36:1611-1618
Wang, Amy Y; Weiner, Howard; Green, Margaret et al. (2018) A phase I study of selinexor in combination with high-dose cytarabine and mitoxantrone for remission induction in patients with acute myeloid leukemia. J Hematol Oncol 11:4
Sample, Ashley; He, Yu-Ying (2018) Mechanisms and prevention of UV-induced melanoma. Photodermatol Photoimmunol Photomed 34:13-24
Jeong, Choongwon; Witonsky, David B; Basnyat, Buddha et al. (2018) Detecting past and ongoing natural selection among ethnically Tibetan women at high altitude in Nepal. PLoS Genet 14:e1007650
Wang, Xin; Wu, Xingye; Zhang, Zhonglin et al. (2018) Monensin inhibits cell proliferation and tumor growth of chemo-resistant pancreatic cancer cells by targeting the EGFR signaling pathway. Sci Rep 8:17914
Brown, Hailey M; Biering, Scott B; Zhu, Allen et al. (2018) Demarcation of Viral Shelters Results in Destruction by Membranolytic GTPases: Antiviral Function of Autophagy Proteins and Interferon-Inducible GTPases. Bioessays 40:e1700231
Karrison, Theodore; Kocherginsky, Masha (2018) Restricted mean survival time: Does covariate adjustment improve precision in randomized clinical trials? Clin Trials 15:178-188

Showing the most recent 10 out of 668 publications