This proposal requests funding for years 16-20 of the UCSF Biology of Infectious Diseases Training Program to train physician-scientists in infectious diseases translational research, both clinical and laboratory-based, for research-intensive or research-related careers in academia, industry, and the public health sector. Funding is requested for four postdoctoral trainees per year, MDs or MDs with dual degrees, recruited from the UCSF Adult Infectious Diseases and the Pediatrics Infectious Diseases Fellowship Programs. This training program is designed to provide flexible but rigorous protected research training in relevant laboratory-based, translational, and clinical research in the areas of epidemiology, public health, global health, HIV/AIDS, genomics, antimicrobial resistance, microbial pathogenesis and host response, and immunology. The 31 faculty are drawn from 6 participating departments from the UCSF School of Medicine (Adult Infectious Diseases, Biochemistry and Biophysics, Epidemiology and Biostatistics, Experimental Medicine, Microbiology and Immunology, Pediatric Infectious Diseases) and the University of California, Berkeley School of Public Health Division of Infectious Diseases and Vaccinology. Participating faculty have been selected on the basis of research area and expertise, funding, productivity, and proven success in training and mentoring post- doctoral fellows. Each fellow will undertake an in-depth research project supervised by one or more of the participating faculty. Emphasis is placed on personalized training and instruction. The educational program provides for special courses, small group conferences, research conferences and seminars, coursework in immunology, microbial pathogenesis, biostatistics, epidemiology, study design, scientific writing, and responsible conduct of research. The quality and effectiveness of the program is measured by the success of trainees in completion of fellowship training, the number and quality of publications in peer-reviewed journals and research presentations, obtaining research funding (e.g., independent research awards, K-awards or equivalent career-development awards, R01-level or equivalent awards), and attainment of a research-oriented career as medical school faculty, in industry, or in the public health sector. The career development component continues to be strengthened through a process of regular and rigorous review and feedback of progress and performance to assure that trainees achieve their career goals. Of the 42 fellows supported by the training program since 2000, 35 (83%) are still in health-related careers, underscoring the extraordinary success of our training program. Funding is requested to continue this highly successful program.

Public Health Relevance

Infectious diseases are the third most common cause of death in the United States, despite availability of antibiotics, vaccines, and high standards of public health, and the leading cause of death worldwide. Our program supports training of infectious diseases specialists in laboratory and clinical sciences to prepare them for careers in academia, industry, and the public health sector in the treatment, control, and prevention of infectious diseases.

National Institute of Health (NIH)
National Institute of Allergy and Infectious Diseases (NIAID)
Institutional National Research Service Award (T32)
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Study Section
Microbiology and Infectious Diseases B Subcommittee (MID)
Program Officer
Robbins, Christiane M
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University of California San Francisco
Internal Medicine/Medicine
Schools of Medicine
San Francisco
United States
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Publicover, Jean; Gaggar, Anuj; Jespersen, Jillian M et al. (2018) An OX40/OX40L interaction directs successful immunity to hepatitis B virus. Sci Transl Med 10:
Patel, Rena C; Leddy, Anna M; Odoyo, Josephine et al. (2018) What motivates serodiscordant couples to prevent HIV transmission within their relationships: findings from a PrEP implementation study in Kenya. Cult Health Sex 20:625-639
Brown, Lillian; Langelier, Charles; Reid, Michael J A et al. (2017) Antimicrobial Resistance: A Call to Action! Clin Infect Dis 64:106-107
Langelier, Charles; Christenson, Stephanie A (2016) An Expression of Clinical Significance: Exploring the Human Genome to Understand the Variable Response to Rhinovirus. Am J Respir Crit Care Med 193:710-2
Solomon, Marc M; Schechter, Mauro; Liu, Albert Y et al. (2016) The Safety of Tenofovir-Emtricitabine for HIV Pre-Exposure Prophylaxis (PrEP) in Individuals With Active Hepatitis B. J Acquir Immune Defic Syndr 71:281-6
Sserwanga, Asadu; Sears, David; Kapella, Bryan K et al. (2015) Anti-malarial prescription practices among children admitted to six public hospitals in Uganda from 2011 to 2013. Malar J 14:331
Rosenberg, Oren S; Dovala, Dustin; Li, Xueming et al. (2015) Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion. Cell 161:501-512
Hagey, Jill M; Akama, Eliud; Ayieko, James et al. (2015) Barriers and facilitators adolescent females living with HIV face in accessing contraceptive services: a qualitative assessment of providers' perceptions in western Kenya. J Int AIDS Soc 18:20123
Woolston, Sophie; Cohen, Stephanie E; Fanfair, Robyn Neblett et al. (2015) A Cluster of Ocular Syphilis Cases - Seattle, Washington, and San Francisco, California, 2014-2015. MMWR Morb Mortal Wkly Rep 64:1150-1
Sears, David; Mpimbaza, Arthur; Kigozi, Ruth et al. (2015) Quality of inpatient pediatric case management for four leading causes of child mortality at six government-run Ugandan hospitals. PLoS One 10:e0127192

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