The University of Chicago Genomics Core Facility (GCF) is committed to providing on-campus biomedical researchers (ranging from experts in the field of genomics to those unfamiliar with whole genome and bioinformatics approaches) with access to state-of-the-art genomics resources (next- Generation Sequencing, DNA microarrays, Sanger Sequencing and non-array based genotyping). The GCF was created in 2006 through the merger of two existing University of Chicago Facilities (the UCCCC-supported DNA Sequencing and Genotyping Facility and the Functional Genomics Facility). The GCF continued to offer access to the main genomics services already provided (Sanger sequencing, DNA microarrays, and array-associated bioinformatics support), while adding next-generation sequencing (NGS) services and NGS-associated bioinformatics support. The merger provided a single on-campus contact point for end-users to fulfill all their genomics needs while operationally eliminating the need for many duplicate pieces of auxiliary equipment (e.g., Nanodrop, Bio-Analyzer), as well as allowing far greater flexibility in managing the human work force as demand for services shift over time. Currently, the GCF is operating as two tightly interactive data generating subunits, """"""""Next-Generation Sequencing and Microarrays"""""""" and """"""""DNA Sequencing and Genotyping"""""""", housed together in the Knapp Center for Biomedical Discovery (KCBD) since 2009. lllumina and LifeTech NGS services were added in 2010-2011, and an overall GCF Operational Director, was hired in 2011. Also in 2011, the data analysis component ofthe GCF (primarily microarray support) was incorporated into the newly created Bioinformatics Facility at the University of Chicago to avoid duplication of services.

Public Health Relevance

The GCF provides access to state-of-the-art genomics platforms. These resources have become so integral to cutting-edge research in the biological sciences that virtually every investigator will access them on a regular basis making on-campus access to these resources invaluable to both expert and novice genomics investigators.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Chicago
United States
Zip Code
Hope, C Matthew; Webber, Jemma L; Tokamov, Sherzod A et al. (2018) Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression. Elife 7:
Wu, Chengyue; Pineda, Federico; Hormuth 2nd, David A et al. (2018) Quantitative analysis of vascular properties derived from ultrafast DCE-MRI to discriminate malignant and benign breast tumors. Magn Reson Med :
Wong, Gabrielle S; Zhou, Jin; Liu, Jie Bin et al. (2018) Targeting wild-type KRAS-amplified gastroesophageal cancer through combined MEK and SHP2 inhibition. Nat Med 24:968-977
Ni, Kaiyuan; Lan, Guangxu; Chan, Christina et al. (2018) Nanoscale metal-organic frameworks enhance radiotherapy to potentiate checkpoint blockade immunotherapy. Nat Commun 9:2351
Meisel, Marlies; Hinterleitner, Reinhard; Pacis, Alain et al. (2018) Microbial signals drive pre-leukaemic myeloproliferation in a Tet2-deficient host. Nature 557:580-584
Webber, Jemma L; Zhang, Jie; Massey, Alex et al. (2018) Collaborative repressive action of the antagonistic ETS transcription factors Pointed and Yan fine-tunes gene expression to confer robustness in Drosophila. Development 145:
Wei, Jiangbo; Liu, Fange; Lu, Zhike et al. (2018) Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and Cytoplasm. Mol Cell 71:973-985.e5
Boisclair Lachance, Jean-Fran├žois; Webber, Jemma L; Hong, Lu et al. (2018) Cooperative recruitment of Yan via a high-affinity ETS supersite organizes repression to confer specificity and robustness to cardiac cell fate specification. Genes Dev 32:389-401
Szmulewitz, Russell Z; Peer, Cody J; Ibraheem, Abiola et al. (2018) Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer. J Clin Oncol 36:1389-1395
Kudron, Michelle M; Victorsen, Alec; Gevirtzman, Louis et al. (2018) The ModERN Resource: Genome-Wide Binding Profiles for Hundreds of Drosophila and Caenorhabditis elegans Transcription Factors. Genetics 208:937-949

Showing the most recent 10 out of 668 publications