The goal of the Animal Procedures Core Facility is to provide a central facility staffed by two skilled individuals to promote reproducible experimentation in laboratory animals. Services include drug screening, tumorigenicity testing and reagent production and small animal colony management. The Core is led by Dr. Bernard Weissman and Ms. Natalie Edmunds. The Core adds value to the Center by providing the animal tumor model expertise lacking in most laboratories, reducing the overall cost of such studies, ensuring a high level of reproducibility for animal studies and fostering interactions between Cancer Center members. Highlights of research supported by the Core include: highly-skilled maneuvers to characterize novel antineoplastic reagents including: intra-tibial inoculations, oral garage, and new treatments of NPC tumors with adenoviral reagents. Future plans for the Core include the addition of new Cancer Center users, expansion of colony management services including genotyping in conjunction with the Animal Models Core Facility and integration of small animal imaging with the new Small Animal Imaging Core Facility.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of North Carolina Chapel Hill
Chapel Hill
United States
Zip Code
Brewer, Noel T; Parada Jr, Humberto; Hall, Marissa G et al. (2018) Understanding Why Pictorial Cigarette Pack Warnings Increase Quit Attempts. Ann Behav Med :
Hall, Marissa G; Sheeran, Paschal; Noar, Seth M et al. (2018) Negative affect, message reactance and perceived risk: how do pictorial cigarette pack warnings change quit intentions? Tob Control 27:e136-e142
Yang, Yanyan; Adebali, Ogun; Wu, Gang et al. (2018) Cisplatin-DNA adduct repair of transcribed genes is controlled by two circadian programs in mouse tissues. Proc Natl Acad Sci U S A 115:E4777-E4785
Kudlacek, Stephan T; Premkumar, Lakshmanane; Metz, Stefan W et al. (2018) Physiological temperatures reduce dimerization of dengue and Zika virus recombinant envelope proteins. J Biol Chem 293:8922-8933
Woappi, Yvon; Hosseinipour, Maria; Creek, Kim E et al. (2018) Stem Cell Properties of Normal Human Keratinocytes Determine Transformation Responses to Human Papillomavirus 16 DNA. J Virol 92:
Collins, Kyla A L; Stuhlmiller, Timothy J; Zawistowski, Jon S et al. (2018) Proteomic analysis defines kinase taxonomies specific for subtypes of breast cancer. Oncotarget 9:15480-15497
Corcoran, Ryan B; André, Thierry; Atreya, Chloe E et al. (2018) Combined BRAF, EGFR, and MEK Inhibition in Patients with BRAFV600E-Mutant Colorectal Cancer. Cancer Discov 8:428-443
St Louis, Lauren E; Rodriguez, Tayliz M; Waters, Marcey L (2018) A study of 2-component i, i?+?3 peptide stapling using thioethers. Bioorg Med Chem 26:1203-1205
Moinova, Helen R; LaFramboise, Thomas; Lutterbaugh, James D et al. (2018) Identifying DNA methylation biomarkers for non-endoscopic detection of Barrett's esophagus. Sci Transl Med 10:
Mi, Yu; Smith, Christof C; Yang, Feifei et al. (2018) A Dual Immunotherapy Nanoparticle Improves T-Cell Activation and Cancer Immunotherapy. Adv Mater 30:e1706098

Showing the most recent 10 out of 1525 publications