Abstract

This proposal is a continuation application for a Specialized Cancer Research Center grant with emphasis on basic research encompassing chemical carcinogenesis, immunobiology, molecular and cell biology and viral oncology. Our objective is to maintain a multidisciplinary specialized cancer center as a logical extension of our current cancer research programs. We are continuing our basic and clinical science research programs and are continuing to develop and provide quality clinical care, treatment, and diagnosis for the cancer patient as a direct benefit of this multidisciplinary approach. This continuation will enable us to continue to provide centralized administrative and support activities for the orderly and efficient development of our oncology research program and also to ensure additional collaborative efforts between investigators working on diverse aspects of the problems associated with neoplasia.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA018450-08S1
Application #
3101621
Study Section
(SRC)
Project Start
1976-06-30
Project End
1987-03-31
Budget Start
1984-04-01
Budget End
1987-03-31
Support Year
8
Fiscal Year
1985
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Cohen, C; Sharkey, F E; Shulman, G et al. (1987) Tumor-associated antigens in breast carcinomas. Prognostic significance. Cancer 60:1294-8
Shirahata, A; Christman, K L; Pegg, A E (1985) Quantitation of S-adenosylmethionine decarboxylase protein. Biochemistry 24:4417-23
Dolan, M E; Corsico, C D; Pegg, A E (1985) Exposure of HeLa cells to 0(6)-alkylguanines increases sensitivity to the cytotoxic effects of alkylating agents. Biochem Biophys Res Commun 132:178-85
Sharkey, F E; Greiner, A S (1985) Morphologic identity of primary tumor and axillary metastases in breast carcinoma. A quantitative study. Arch Pathol Lab Med 109:256-9
Sharkey, F E; Spicer, J H; Fogh, J (1985) Changes in histological differentiation of human tumors transplanted to athymic nude mice: a morphometric study. Exp Cell Biol 53:100-6
Barry, J D; Sharkey, F E (1985) Observer reproducibility during computer-assisted planimetric measurements of nuclear features. Hum Pathol 16:225-7
Dolan, M E; Pegg, A E (1985) Extent of formation of O4-methylthymidine in calf thymus DNA methylated by N-methyl-N-nitrosourea and lack of repair of this product by rat liver O6-alkylguanine-DNA-alkyltransferase. Carcinogenesis 6:1611-4
Dolan, M E; Morimoto, K; Pegg, A E (1985) Reduction of O6-alkylguanine-DNA alkyltransferase activity in HeLa cells treated with O6-alkylguanines. Cancer Res 45:6413-7
Lehner, A F; Hill, C W (1985) Merodiploidy in Escherichia coli-Salmonella typhimurium crosses: the role of unequal recombination between ribosomal RNA genes. Genetics 110:365-80