Biostatistics and Bioinformatics The Biostatistics and Bioinformatics Shared Resource (BBSR) offers comprehensive statistical and bioinformatics consultation, collaboration, and technical services to all Norris Cotton Cancer Center (NCCC) Programs. All BBSR statisticians and bioinformaticians are equipped with state-of-the-art workstations with general and specialty statistical packages, such as SAS, R, RStudio, PASS, NQuery, SPSS, MPlus, and Winbugs. High-performance computing relies on access to a 2000+ processor parallel computer cluster (Discovery). Ten (10) faculty from the Departments of Biomedical Data Sciences, The Dartmouth Institute, and Pediatrics serve as scientific collaborators in clinical trial and research design, advise on and participate in statistical study management, perform statistical oversight, and conduct data analyses. State-of-the-art capabilities are evident in BBSR faculty having obtained two PCORI Methodology Awards, two NIH R01s, and two individual K01s during the current funding period. Since the last review, four new faculty have joined the Shared Resource (i.e., Drs. Frost [CBT], Emond [CPS], Gorlov [CPS] and Moen [CPS]), strengthening support for behavioral research and network analysis, and formerly separate Biostatistics and Bioinformatics resources have been merged to better coordinate faculty expertise and take advantage of administrative efficiencies. More than 300 peer-reviewed cancer-related publications involving BBSR faculty as co-authors appeared in the current reporting period. The breadth of BBSR impact is evident in examples of the development of collaboration with Cancer Population Sciences investigators on specialized statistical methods for analyzing terminal declines in quality of life, gene set enrichment analyses performed with the Cancer Biology and Therapeutics Program to identify pathways presenting potential therapeutic opportunity, and advanced image processing and machine learning to assist Translational Engineering in Cancer investigators in cancer detection. The Division of Biostatistics in the new Department of Biomedical Science serves as the BBSR organizational home, but nine of the 10 faculty are housed on site in the NCCC Rubin Building. Dr. Tor Tosteson (CPS) has served as Shared Resource Director for more than 20 years. Faculty meet monthly to coordinate activities, and a second faculty member provides an independent review of protocols and internally- funded projects with a BBSR co-investigator. During the current reporting period, 126 BBSR clients were NCCC Members at the time of service (CPS [62], CBT [33], ICI [16], TEC [15]). 56 NCCC Members, in addition to 300 publications, collaborated on 62 grant applications. Funded NCCC Members represented 29% (73) of Total Users, and we are requesting only 13% of the Total BBSR budget from CCSG support. New initiatives to augment services to NCCC Members include formal designation of BBSR faculty for participation on mentoring committees. Additionally, walk-in clinics are being established for short consult requiring primarily quick advice for researchers at many levels of statistical sophistication.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
Project #
Application #
Study Section
Subcommittee I - Transistion to Independence (NCI)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Dartmouth College
United States
Zip Code
Elder, David E; Piepkorn, Michael W; Barnhill, Raymond L et al. (2018) Pathologist characteristics associated with accuracy and reproducibility of melanocytic skin lesion interpretation. J Am Acad Dermatol 79:52-59.e5
Rutter, Carolyn M; Kim, Jane J; Meester, Reinier G S et al. (2018) Effect of Time to Diagnostic Testing for Breast, Cervical, and Colorectal Cancer Screening Abnormalities on Screening Efficacy: A Modeling Study. Cancer Epidemiol Biomarkers Prev 27:158-164
Lin, Anping; Yin, Juan; Cheng, Chao et al. (2018) Decreased expression of FOXA2 promotes eutopic endometrial cell proliferation and migration in patients with endometriosis. Reprod Biomed Online 36:181-187
Punshon, Tracy; Jackson, Brian P (2018) Essential micronutrient and toxic trace element concentrations in gluten containing and gluten-free foods. Food Chem 252:258-264
Pernas, Sonia; Martin, Miguel; Kaufman, Peter A et al. (2018) Balixafortide plus eribulin in HER2-negative metastatic breast cancer: a phase 1, single-arm, dose-escalation trial. Lancet Oncol 19:812-824
Kumar, Nishant; Tafe, Laura J; Higgins, John H et al. (2018) Identifying Associations between Somatic Mutations and Clinicopathologic Findings in Lung Cancer Pathology Reports. Methods Inf Med 57:63-73
Skolasky, Richard L; Scherer, Emily A; Wegener, Stephen T et al. (2018) Does reduction in sciatica symptoms precede improvement in disability and physical health among those treated surgically for intervertebral disc herniation? Analysis of temporal patterns in data from the Spine Patient Outcomes Research Trial. Spine J 18:1318-1324
Doubeni, Chyke A; Gabler, Nicole B; Wheeler, Cosette M et al. (2018) Timely follow-up of positive cancer screening results: A systematic review and recommendations from the PROSPR Consortium. CA Cancer J Clin 68:199-216
Svedbom, Axel; Borgström, Fredrik; Hernlund, Emma et al. (2018) Quality of life after hip, vertebral, and distal forearm fragility fractures measured using the EQ-5D-3L, EQ-VAS, and time-trade-off: results from the ICUROS. Qual Life Res 27:707-716
Li, Bo; Wang, Yanru; Xu, Yinghui et al. (2018) Genetic variants in RORA and DNMT1 associated with cutaneous melanoma survival. Int J Cancer 142:2303-2312

Showing the most recent 10 out of 1911 publications