During the past five years the CNRU Immunology Core Laboratory has worked to facilitate the study of nutrition, immunity and cancer prevention by providing a comprehensive battery of immunological tests for nutrition oriented investigators of the Cooperative Core Laboratory and Clinical Nutrition Research Unit and the biomedical community: The American Health Foundation, Memorials Sloan-Kettering Cancer Center, Cornell University Weill Medical College-New York Presbyterian Hospital, The Strang Cancer Prevention Center, The Rockefeller University, and in the future the Westchester Medical Center-New York Medical College. A second major function of the Core laboratory is to serve as educators and consultants to investigators in study design, in the selection of tests and in the interpretation of data. A related third goal has been to develop new methodologies and to refine existing techniques that are potentially useful for new and evolving CNRU investigations. The focus of the Immunology Core Laboratory is to undertake studies relating immunological function to nutrient status, cancer prevention and control. The development of new immunological approaches including technology and standardization were initially crucial for this work (1-4). This has been a continuing theme during the past five years (5-8) with the evolution of more sensitive and well standardized techniques.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA029502-20
Application #
6656439
Study Section
Project Start
2002-09-10
Project End
2003-03-31
Budget Start
Budget End
Support Year
20
Fiscal Year
2002
Total Cost
Indirect Cost
Name
Sloan-Kettering Institute for Cancer Research
Department
Type
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10065
Telang, Nitin (2018) Anti-inflammatory drug resistance selects putative cancer stem cells in a cellular model for genetically predisposed colon cancer. Oncol Lett 15:642-648
Telang, Nitin (2015) Putative cancer-initiating stem cells in cell culture models for molecular subtypes of clinical breast cancer. Oncol Lett 10:3840-3846
Telang, Nitin; Katdare, Meena (2011) Preclinical in vitro models from genetically engineered mice for breast and colon cancer (Review). Oncol Rep 25:1195-201
Protiva, Petr; Mason, Joel B; Liu, Zhenhua et al. (2011) Altered folate availability modifies the molecular environment of the human colorectum: implications for colorectal carcinogenesis. Cancer Prev Res (Phila) 4:530-43
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Hsieh, Tze-chen; Wu, Joseph M (2010) Resveratrol: Biological and pharmaceutical properties as anticancer molecule. Biofactors 36:360-9
Cheng, Yu-Wei; Idrees, Kamran; Shattock, Richard et al. (2010) Loss of imprinting and marked gene elevation are 2 forms of aberrant IGF2 expression in colorectal cancer. Int J Cancer 127:568-77
Moon, Aeri; Solomon, Aliza; Beneck, Debra et al. (2009) Positive association between Helicobacter pylori and gastroesophageal reflux disease in children. J Pediatr Gastroenterol Nutr 49:283-8
Cunningham-Rundles, Susanna; Lin, Hong; Ho-Lin, Deborah et al. (2009) Role of nutrients in the development of neonatal immune response. Nutr Rev 67 Suppl 2:S152-63
Spangler, Rudolph; Goddard, Noel L; Spangler, Douglas N et al. (2009) Tests of the single-hit DNA damage model. J Mol Biol 392:283-300

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