Developmental Funds ABSTRACT The City of Hope Comprehensive Cancer Center requests CCSG developmental funds to support pilot research projects and developing an additional new shared resources to strengthen research initiatives and promote basic, translational and clinical science research activities. Funding pilot projects and developing shared resources will collectively enhance the ability of the COHCCC to serve the catchment area and mitigate the impact of cancer in the region. COHCCC believes that these activities will enable the Cancer Center to provide the optimal environment to focus the power of precision medicine, basic science inquiry, drug discovery and development, and behavioral interventions to decrease cancer incidence, morbidity, and mortality. The plan for the next funding cycle is to develop a new Multi-Scale Translational Research Core. Multi-scale modeling uses computational analysis to integrate linked measurements made at different scales of measurement (populations, individuals, microenvironment, cells, DNA/RNA/protein, and analytes). Over the past 3 years, the scope City of Hope Comprehensive Cancer Center (COHCCC) Cancer Control and Population Science (CCPS) research has expanded beyond classic epidemiologic testing of associations in large cohorts to biology-focused, translational multi-disciplinary studies that integrate multi-scale data from cohorts with mechanistic mouse-human co-studies, omics (genetics, genomics, proteomics), and analytes (drug levels, endocrine disruptors, carcinogens). The Multi-Scale Translational Research (MSTR) Core in development aims to provide services that facilitate and enhance NCI funded multi-scale research at each level of scale (zip code, individuals, microenvironment, cells, DNA/RNA/protein, and analytes). Multi-scale modeling requires integration of large data sets; to this end, the Core will provide services in data curation, annotation, validation, and assessment of rigor. To support NIH funded COHCCC multi-scale projects, the MSTR Core in development will 1) offer unique services and 2) collaborate and integrate with COHCCC Cores and Caltech, ORIONTM, and TGenTM partners. Unique services offered by the MSTR Core in development include 1) expertise in multi-scale modeling, 2) curation, annotation, and validation of the rigor, reproducibility, and accuracy of tissue, omic, and analyte data, 3) genetic admixture assessment, 4) navigation of existing COH analyte services, 4) expertise in custom tissue engineering and microenvironment studies, 5) cloud-based image storage and sharing services for national and international cohort development. The MSTR in development will deliver this wide range of services through a dedicated team of senior scientists with expertise in precision medicine, tissue engineering, genetic admixture, analyte identification, bioinformatics, and multi-scale modeling.
| Aslamy, Arianne; Oh, Eunjin; Olson, Erika M et al. (2018) Doc2b Protects ?-Cells Against Inflammatory Damage and Enhances Function. Diabetes 67:1332-1344 |
| Zhao, Xingli; Zhang, Zhuoran; Moreira, Dayson et al. (2018) B Cell Lymphoma Immunotherapy Using TLR9-Targeted Oligonucleotide STAT3 Inhibitors. Mol Ther 26:695-707 |
| Weitzel, Jeffrey N; Chao, Elizabeth C; Nehoray, Bita et al. (2018) Somatic TP53 variants frequently confound germ-line testing results. Genet Med 20:809-816 |
| Ghose, Jayeeta; Viola, Domenico; Terrazas, Cesar et al. (2018) Daratumumab induces CD38 internalization and impairs myeloma cell adhesion. Oncoimmunology 7:e1486948 |
| Castanotto, Daniela; Zhang, Xiaowei; Alluin, Jessica et al. (2018) A stress-induced response complex (SIRC) shuttles miRNAs, siRNAs, and oligonucleotides to the nucleus. Proc Natl Acad Sci U S A 115:E5756-E5765 |
| Awasthi, Sanjay; Tompkins, Joshua; Singhal, Jyotsana et al. (2018) Rlip depletion prevents spontaneous neoplasia in TP53 null mice. Proc Natl Acad Sci U S A 115:3918-3923 |
| Röth, Daniel; Chiang, Abby J; Hu, Weidong et al. (2018) Two-carbon folate cycle of commensal Lactobacillus reuteri 6475 gives rise to immunomodulatory ethionine, a source for histone ethylation. FASEB J :fj201801848R |
| Li, Yi-Jia; Du, Li; Aldana-Masangkay, Grace et al. (2018) Regulation of miR-34b/c-targeted gene expression program by SUMOylation. Nucleic Acids Res 46:7108-7123 |
| Maestrini, Davide; Abler, Daniel; Adhikarla, Vikram et al. (2018) Aging in a Relativistic Biological Space-Time. Front Cell Dev Biol 6:55 |
| Adamus, Tomasz; Kortylewski, Marcin (2018) The revival of CpG oligonucleotide-based cancer immunotherapies. Contemp Oncol (Pozn) 22:56-60 |
Showing the most recent 10 out of 1396 publications
