Developmental Funds ABSTRACT The City of Hope Comprehensive Cancer Center requests CCSG developmental funds to support pilot research projects and developing an additional new shared resources to strengthen research initiatives and promote basic, translational and clinical science research activities. Funding pilot projects and developing shared resources will collectively enhance the ability of the COHCCC to serve the catchment area and mitigate the impact of cancer in the region. COHCCC believes that these activities will enable the Cancer Center to provide the optimal environment to focus the power of precision medicine, basic science inquiry, drug discovery and development, and behavioral interventions to decrease cancer incidence, morbidity, and mortality. The plan for the next funding cycle is to develop a new Multi-Scale Translational Research Core. Multi-scale modeling uses computational analysis to integrate linked measurements made at different scales of measurement (populations, individuals, microenvironment, cells, DNA/RNA/protein, and analytes). Over the past 3 years, the scope City of Hope Comprehensive Cancer Center (COHCCC) Cancer Control and Population Science (CCPS) research has expanded beyond classic epidemiologic testing of associations in large cohorts to biology-focused, translational multi-disciplinary studies that integrate multi-scale data from cohorts with mechanistic mouse-human co-studies, omics (genetics, genomics, proteomics), and analytes (drug levels, endocrine disruptors, carcinogens). The Multi-Scale Translational Research (MSTR) Core in development aims to provide services that facilitate and enhance NCI funded multi-scale research at each level of scale (zip code, individuals, microenvironment, cells, DNA/RNA/protein, and analytes). Multi-scale modeling requires integration of large data sets; to this end, the Core will provide services in data curation, annotation, validation, and assessment of rigor. To support NIH funded COHCCC multi-scale projects, the MSTR Core in development will 1) offer unique services and 2) collaborate and integrate with COHCCC Cores and Caltech, ORIONTM, and TGenTM partners. Unique services offered by the MSTR Core in development include 1) expertise in multi-scale modeling, 2) curation, annotation, and validation of the rigor, reproducibility, and accuracy of tissue, omic, and analyte data, 3) genetic admixture assessment, 4) navigation of existing COH analyte services, 4) expertise in custom tissue engineering and microenvironment studies, 5) cloud-based image storage and sharing services for national and international cohort development. The MSTR in development will deliver this wide range of services through a dedicated team of senior scientists with expertise in precision medicine, tissue engineering, genetic admixture, analyte identification, bioinformatics, and multi-scale modeling.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
3P30CA033572-35S1
Application #
9756951
Study Section
Subcommittee I - Transistion to Independence (NCI)
Program Officer
Roberson, Sonya
Project Start
Project End
Budget Start
2018-04-20
Budget End
2018-11-30
Support Year
35
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Beckman Research Institute/City of Hope
Department
Type
DUNS #
027176833
City
Duarte
State
CA
Country
United States
Zip Code
91010
Querfeld, Christiane; Leung, Samantha; Myskowski, Patricia L et al. (2018) Primary T Cells from Cutaneous T-cell Lymphoma Skin Explants Display an Exhausted Immune Checkpoint Profile. Cancer Immunol Res 6:900-909
Liu, Xuxiang; Cao, Minghui; Palomares, Melanie et al. (2018) Metastatic breast cancer cells overexpress and secrete miR-218 to regulate type I collagen deposition by osteoblasts. Breast Cancer Res 20:127
Das, Sadhan; Reddy, Marpadga A; Senapati, Parijat et al. (2018) Diabetes Mellitus-Induced Long Noncoding RNA Dnm3os Regulates Macrophage Functions and Inflammation via Nuclear Mechanisms. Arterioscler Thromb Vasc Biol 38:1806-1820
Al Malki, Monzr M; Nathwani, Nitya; Yang, Dongyun et al. (2018) Melphalan-Based Reduced-Intensity Conditioning is Associated with Favorable Disease Control and Acceptable Toxicities in Patients Older Than 70 with Hematologic Malignancies Undergoing Allogeneic Hematopoietic Stem Cell Transplantation. Biol Blood Marrow Transplant 24:1828-1835
Chiuppesi, Flavia; Nguyen, Jenny; Park, Soojin et al. (2018) Multiantigenic Modified Vaccinia Virus Ankara Vaccine Vectors To Elicit Potent Humoral and Cellular Immune Reponses against Human Cytomegalovirus in Mice. J Virol 92:
Petrossian, Karineh; Kanaya, Noriko; Lo, Chiao et al. (2018) ER?-mediated cell cycle progression is an important requisite for CDK4/6 inhibitor response in HR+ breast cancer. Oncotarget 9:27736-27751
Ambaye, Nigus; Chen, Chih-Hong; Khanna, Swati et al. (2018) Streptonigrin Inhibits SENP1 and Reduces the Protein Level of Hypoxia-Inducible Factor 1? (HIF1?) in Cells. Biochemistry 57:1807-1813
Bosworth, Alysia; Goodman, Elizabeth L; Wu, Eric et al. (2018) The Minneapolis-Manchester Quality of Life Instrument: reliability and validity of the Adult Form in cancer survivors. Qual Life Res 27:321-332
Vu, Binh Thanh; Shahin, Sophia Allaf; Croissant, Jonas et al. (2018) Chick chorioallantoic membrane assay as an in vivo model to study the effect of nanoparticle-based anticancer drugs in ovarian cancer. Sci Rep 8:8524
Yan, Wei; Wu, Xiwei; Zhou, Weiying et al. (2018) Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. Nat Cell Biol 20:597-609

Showing the most recent 10 out of 1396 publications