The Huntsman Cancer Institute (HCI) is a designated research unit of the University of Utah. It was formed in July 1994, from the previous, NCI-designate Utah Regional Cancer Center, with major funding provided in late 1995 by the Jon M. Huntsman family, through the Huntsman Cancer Foundation. The mission of the HCI is the translation of molecular and genetic discoveries in the mechanisms of carcinogenesis into clinically effective diagnostics and therapies. The Institute's primary focus on understanding and intervening in the earliest events in the carcinogenesis pathways, at the level of the cancer precursor cell, leads to a strong emphasis on identifying the inherited components of cancer predisposition, as these components are often among the earliest steps in the carcinogenesis pathways. This orientation stem's from the University's history in the development and use of molecular genetic tools for mapping of human disease genes, in particular the genes that predispose to cancer. The Cancer Center is organized into six programs; three basic science programs-Cell Response and Regulation, Molecular Pharmacology, and Nuclear Control of Cell Growth and Differentiation and three disease-focused programs-Brain, Colon and Hematology. Fourteen research resource facilities service these programs; seven of these are new facilities established since the last competitive renewal. In this application, we are requesting funds in the amount of $1.2 million, 46 percent of which will support shared resource facilities, 26 percent professional and administrative personnel, and 25 percent for development. The leadership of the HCI and the University of Utah are committed to the efforts of the Cancer Center. Raymond L. White, Ph.D., is the Executive Director of the HCI and the Principal Investigator of the Cancer Center Support Grant. His laboratory has been heavily involved in studies of genes that predispose to cancer for nearly two decades. Furthermore, the ice President and Dean of the Health Sciences Center at the University provides strong institutional support in the form of space and core resources for the institute's scientific endeavors.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Study Section
Subcommittee G - Education (NCI)
Program Officer
Ptak, Krzysztof
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University of Utah
Internal Medicine/Medicine
Schools of Medicine
Salt Lake City
United States
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Zeng, Tao; Fleming, Aaron M; Ding, Yun et al. (2018) Nanopore Analysis of the 5-Guanidinohydantoin to Iminoallantoin Isomerization in Duplex DNA. J Org Chem 83:3973-3978
Himbert, Caroline; Ose, Jennifer; Nattenm├╝ller, Johanna et al. (2018) Body fatness, adipose tissue compartments and biomarkers of inflammation and angiogenesis in colorectal cancer: the ColoCare Study. Cancer Epidemiol Biomarkers Prev :
Madison, Bethany J; Clark, Kathleen A; Bhachech, Niraja et al. (2018) Electrostatic repulsion causes anticooperative DNA binding between tumor suppressor ETS transcription factors and JUN-FOS at composite DNA sites. J Biol Chem 293:18624-18635
Arbeeva, Liubov S; Hanson, Heidi A; Arbeev, Konstantin G et al. (2018) How Well Does the Family Longevity Selection Score Work: A Validation Test Using the Utah Population Database. Front Public Health 6:277
Patel, Ami B; Lange, Thoralf; Pomicter, Anthony D et al. (2018) Similar expression profiles in CD34+ cells from chronic phase chronic myeloid leukemia patients with and without deep molecular responses to nilotinib. Oncotarget 9:17889-17894
De, Shrutokirti; Van Deren, Donn; Peden, Eric et al. (2018) Two distinct ontogenies confer heterogeneity to mouse brain microglia. Development 145:
Giraddi, Rajshekhar R; Chung, Chi-Yeh; Heinz, Richard E et al. (2018) Single-Cell Transcriptomes Distinguish Stem Cell State Changes and Lineage Specification Programs in Early Mammary Gland Development. Cell Rep 24:1653-1666.e7
Doherty, Jennifer A; Grieshober, Laurie; Houck, John R et al. (2018) Telomere Length and Lung Cancer Mortality among Heavy Smokers. Cancer Epidemiol Biomarkers Prev 27:829-837
Kleinstern, Geffen; Camp, Nicola J; Goldin, Lynn R et al. (2018) Association of polygenic risk score with the risk of chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis. Blood 131:2541-2551
Wagner, Alex H; Devarakonda, Siddhartha; Skidmore, Zachary L et al. (2018) Recurrent WNT pathway alterations are frequent in relapsed small cell lung cancer. Nat Commun 9:3787

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