Hematopoietic Stem Cell Core Program Director/Principal Investigator: Gerson, Stanton L. PROJECT SUMMARY (See Instmctions): The Case CCC Hematopoietic Stem Cell Core provides for the procurement, processing, production. Storage, banking, analysis and distribution of cells derived from human blood, bone marrow, and umbilical cords. The Core is composed of two components: 1) A human hematopoietic biorepository and support services to facilitate basic hematopoietic research, and 2) A cellular therapy facility that supports clinical grade cell manufacturing for investigational and standard-of-care therapy. The biorepository procures, processes, banks and distributes human cells from a variety of sources for researchers under an Institutional Review Board (IRB)-approved protocol. This facility obviates the need for Cancer Center members to invest in specialized stem cell reagents and procedures as well as the need to identify and procure blood or bone marrow samples from normal donors and patients with specific hematologic disorders The cellular therapy component of the Core, designated as the Cellular Therapy Service, supports clinical cellular therapy activities from the preclinical phase through clinical trial implementation. While the heaviest use of the Core is by members of the Hematopoietic Disorders Program, the Core has supported work in 6 of the 8 Research Programs of the Cancer Center. In particular, the Core supported work that: investigated the efficacy of novel leukemia therapeutics identified on human AML patient samples as well as determining their myelotoxic effects on normal bone marrow;identified that the combination of fludarabine plus MX represents a potential new clinical targeted therapy;and uses human MSCs to devise a novel model on the trophic and immunomodulatory properties of MSCs that may have important implications in cancer.

Public Health Relevance

The Case Comprehensive Cancer Center is Northeast Ohio's only NCI designated comprehensive cancer center providing bench-to-bedside medical research involving partnerships between basic, clinical and population scientists to speed translation of laboratory discoveries into new prevention/intervention and cancer treatments.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA043703-24
Application #
8765399
Study Section
Subcommittee B - Comprehensiveness (NCI)
Project Start
Project End
Budget Start
2014-04-01
Budget End
2015-03-31
Support Year
24
Fiscal Year
2014
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Type
DUNS #
City
Cleveland
State
OH
Country
United States
Zip Code
44106
He, Tian; McColl, Karen; Sakre, Nneha et al. (2018) Post-transcriptional regulation of PIAS3 expression by miR-18a in malignant mesothelioma. Mol Oncol 12:2124-2135
Roche, Kathryn L; Nukui, Masatoshi; Krishna, Benjamin A et al. (2018) Selective 4-Thiouracil Labeling of RNA Transcripts within Latently Infected Cells after Infection with Human Cytomegalovirus Expressing Functional Uracil Phosphoribosyltransferase. J Virol 92:
Bedell, Hillary W; Hermann, John K; Ravikumar, Madhumitha et al. (2018) Targeting CD14 on blood derived cells improves intracortical microelectrode performance. Biomaterials 163:163-173
Nagaraj, A B; Wang, Q Q; Joseph, P et al. (2018) Using a novel computational drug-repositioning approach (DrugPredict) to rapidly identify potent drug candidates for cancer treatment. Oncogene 37:403-414
Somasegar, Sahana; Li, Li; Thompson, Cheryl L (2018) No association of reproductive risk factors with breast cancer tumor grade. Eur J Cancer Prev 27:140-143
Gu, Xiaorong; Ebrahem, Quteba; Mahfouz, Reda Z et al. (2018) Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates. J Clin Invest 128:4260-4279
Bosca, Federica; Bielecki, Peter A; Exner, Agata A et al. (2018) Porphyrin-Loaded Pluronic Nanobubbles: A New US-Activated Agent for Future Theranostic Applications. Bioconjug Chem 29:234-240
Benson, Bryan L; Li, Lucy; Myers, Jay T et al. (2018) Biomimetic post-capillary venule expansions for leukocyte adhesion studies. Sci Rep 8:9328
Morrow, James J; Bayles, Ian; Funnell, Alister P W et al. (2018) Positively selected enhancer elements endow osteosarcoma cells with metastatic competence. Nat Med 24:176-185
Cooper, Gregory S; Markowitz, Sanford D; Chen, Zhengyi et al. (2018) Evaluation of Patients with an Apparent False Positive Stool DNA Test: The Role of Repeat Stool DNA Testing. Dig Dis Sci 63:1449-1453

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