The goal of the Gold Spring Harbor Laboratory Cancer Center is to promote interdisciplinary and high quality basic research on different aspects of cancer. The Cancer Center is organized into four established research programs. The Oncogene Program focuses on the genetics of human cancer and the faction of oncogene products in signal transduction. The Gene Expression Program focuses on the regulation of gene expression in normal and cancer cells and the controls that govern cell growth and division. The Tumor Virus Program concentrates on the mechanisms of virus induced cell transformation and HIV infection in AIDS. This program focuses on fundamental cellular processes such as transcription, DNA replication, messenger RNA splicing and translation as they relate to cancer. The Structure and Computation program studies the function of proteins by X- ray crystallography and conducts research on computer assisted methods for genetic analysis. The Center has a number of Shared Resources that facilitate the research within the Programs, including Animal, Microscopy, Shared Instrumentation, Fluorescent In Situ Hybridization, Flow Cytometry, Monoclonal Antibody, Nucleic Acid Chemistry, Protein Chemistry, Tissue Procurement, Graphic Arts and 2D-Gel facilities, as well as Central Services, Computer Services and Developmental Funds. These Programs and facilities are organized into a coordinated Center with a clearly defined Administrative structure that promotes scientific excellence in cancer research.
| Arun, Gayatri; Diermeier, Sarah D; Spector, David L (2018) Therapeutic Targeting of Long Non-Coding RNAs in Cancer. Trends Mol Med 24:257-277 |
| Giuliano, Christopher J; Lin, Ann; Smith, Joan C et al. (2018) MELK expression correlates with tumor mitotic activity but is not required for cancer growth. Elife 7: |
| Li, Jiahe; Wu, Connie; Wang, Wade et al. (2018) Structurally modulated codelivery of siRNA and Argonaute 2 for enhanced RNA interference. Proc Natl Acad Sci U S A 115:E2696-E2705 |
| Tarumoto, Yusuke; Lu, Bin; Somerville, Tim D D et al. (2018) LKB1, Salt-Inducible Kinases, and MEF2C Are Linked Dependencies in Acute Myeloid Leukemia. Mol Cell 69:1017-1027.e6 |
| Krishnan, Navasona; Konidaris, Konstantis F; Gasser, Gilles et al. (2018) A potent, selective, and orally bioavailable inhibitor of the protein-tyrosine phosphatase PTP1B improves insulin and leptin signaling in animal models. J Biol Chem 293:1517-1525 |
| Borges, Filipe; Parent, Jean-Sébastien; van Ex, Frédéric et al. (2018) Transposon-derived small RNAs triggered by miR845 mediate genome dosage response in Arabidopsis. Nat Genet 50:186-192 |
| Chen, Xiaoyin; Sun, Yu-Chi; Church, George M et al. (2018) Efficient in situ barcode sequencing using padlock probe-based BaristaSeq. Nucleic Acids Res 46:e22 |
| Tonelli, Claudia; Chio, Iok In Christine; Tuveson, David A (2018) Transcriptional Regulation by Nrf2. Antioxid Redox Signal 29:1727-1745 |
| Kumar, Vijay; Rosenbaum, Julie; Wang, Zihua et al. (2018) Partial bisulfite conversion for unique template sequencing. Nucleic Acids Res 46:e10 |
| Lee, Je H (2018) Tracing single-cell histories. Science 359:521-522 |
Showing the most recent 10 out of 380 publications
