The Cancer Development and Progression (CDP) Program is one of three interactive research Programs of the Cancer Therapy and Research Center (CTRC) at the University of Texas Health Science Center at San Antonio (UTHSCSA). The primary focus of the CDP Program is laboratory-based studies of fundamental problems in cancer etiology, but always with an eye towards translational potential. The major thematic areas in the CDP Program are (1) Genomic Integrity and Aging and (2) Hormones and Chronic Inflammation. The overarching scientific objectives of the CDP Program are to: (1) integrate basic and translational research in genomic integrity, age-related cancer susceptibility, hormone actions, and chronic inflammation to obtain a deeper and broader picture of cancer development and progression;(2) foster transdisciplinary, synergistic, and highly complementary collaboration between basic and translational research within the CDP Program and in the EDT and CPPS Programs;and (3) translate laboratory findings into novel approaches in cancer prevention and treatment. The CDP program is comprised of 31 members. Twenty-eight members represent eight departments within the School of Medicine at the UTHSCSA. Two members are from the University of Texas at Austin. The CDP Program members have $7,290,029 of peer-reviewed cancer-related funding (33 grants). Of those, $2,195,289 are from 10 NCI grants. Over the last funding period the CDP Program has 271 peer-reviewed cancer-related publications of which 26% are intra-programmatic collaborafions and 22% are inter-programmatic collaborations.

Public Health Relevance

The Cancer Development and Progression (CDR) Program members perform cutting-edge laboratory-based cancer research to understand fundamental problems in cancer etiology with a continual focus on translational potential.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA054174-20
Application #
8758352
Study Section
Special Emphasis Panel (ZCA1-RTRB-A (M3))
Project Start
1997-08-01
Project End
2019-07-31
Budget Start
2014-09-16
Budget End
2015-07-31
Support Year
20
Fiscal Year
2014
Total Cost
$66,353
Indirect Cost
$39,733
Name
University of Texas Health Science Center
Department
Type
DUNS #
800772162
City
San Antonio
State
TX
Country
United States
Zip Code
78229
Arora, Sukeshi Patel; Mahalingam, Devalingam (2018) Immunotherapy in colorectal cancer: for the select few or all? J Gastrointest Oncol 9:170-179
Arellano, Luisa M; Arora, Sukeshi Patel (2018) Systemic Treatment of Advanced Hepatocellular Carcinoma in Older Adults. J Nat Sci 4:
Du, Liqin; Zhao, Zhenze; Suraokar, Milind et al. (2018) LMO1 functions as an oncogene by regulating TTK expression and correlates with neuroendocrine differentiation of lung cancer. Oncotarget 9:29601-29618
Ankerst, Donna P; Straubinger, Johanna; Selig, Katharina et al. (2018) A Contemporary Prostate Biopsy Risk Calculator Based on Multiple Heterogeneous Cohorts. Eur Urol 74:197-203
Sun, Xiujie; Gupta, Kshama; Wu, Bogang et al. (2018) Tumor-extrinsic discoidin domain receptor 1 promotes mammary tumor growth by regulating adipose stromal interleukin 6 production in mice. J Biol Chem 293:2841-2849
Horning, Aaron M; Wang, Yao; Lin, Che-Kuang et al. (2018) Single-Cell RNA-seq Reveals a Subpopulation of Prostate Cancer Cells with Enhanced Cell-Cycle-Related Transcription and Attenuated Androgen Response. Cancer Res 78:853-864
Gong, Siqi; Tomusange, Khamis; Kulkarni, Viraj et al. (2018) Anti-HIV IgM protects against mucosal SHIV transmission. AIDS 32:F5-F13
Gelfond, Jonathan; Goros, Martin; Hernandez, Brian et al. (2018) A System for an Accountable Data Analysis Process in R. R J 10:6-21
Soteros, Breeanne M; Cong, Qifei; Palmer, Christian R et al. (2018) Sociability and synapse subtype-specific defects in mice lacking SRPX2, a language-associated gene. PLoS One 13:e0199399
Katti, Sachin; Her, Bin; Srivastava, Atul K et al. (2018) High affinity interactions of Pb2+ with synaptotagmin I. Metallomics 10:1211-1222

Showing the most recent 10 out of 989 publications