The Structural Biology and Bioinformatics Program (SBB) consists of 6 NCI-funded investigators who use structural, computational and high- throughput experimental techniques in the area of cancer, pharmacogenomics, defined as the identification, characterization and exploitation of genotype-specific targets for cancer diagnosis, treatment, prevention and control.
The specific aims of this program are: 1) to use computational and high-throughput experimental techniques to identify novel targets and agents in cancer diagnosis, treatment, prevention and control; 2) to use biochemical, structural and chemical approaches to elucidate and to alter gene function in cancer research; and 3) to foster the deployment of computational, high-throughput, biochemical, structural and chemical methods to all basic and clinical programs at the Kimmel Cancer Center.
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|Waldman, Scott A; Camilleri, Michael (2018) Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders. Gut 67:1543-1552|
|Sullivan-Reed, Katherine; Bolton-Gillespie, Elisabeth; Dasgupta, Yashodhara et al. (2018) Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Rep 23:3127-3136|
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|Vido, Michael J; Le, Kaitlyn; Hartsough, Edward J et al. (2018) BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association. Cell Rep 25:1501-1510.e3|
|Brody, Jonathan R; Dixon, Dan A (2018) Complex HuR function in pancreatic cancer cells. Wiley Interdiscip Rev RNA 9:e1469|
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