The Shared Computer Facility is an essential and important computer resource both for basic science and clinical research at the Kimmel Cancer Center, providing shared computer hardware and software infrastructure, software development, and consultative services for computer-related concerns. In support of basic science at KCC, this is the primary Facility for scientist support with DNA/Amino Acid Sequence Analysis, and is a computational resource for the Structural Biology group which includes molecular modeling, NMR and x-ray crystallography. The Shared Computer Facility also support clinical research, providing computer resources for the Clinical Trial Support Services, the Jefferson Cancer Network, various program projects, and individual clinical researchers. Applications have been developed to provide controlled and secure access to clinical data, laboratory data, and protocol information for research and the management of clinical trials. For both KCC basic scientists and clinicians, the Shared Computer Facility provides the basic computing infrastructure, including network-accessible mass (disk) storage, Internet/World-Wide-Web access, and hardware and software experience. The SCF staff works closely with the University's information systems and hardware and software expertise. The SCF staff works closely with the University's information systems department, supplementing the generic network support provided by TJU with more comprehensive services attuned to the specific needs of cancer research. Additionally, SCF staff are available to KCC members for consultation on computer specifications and purchases, hardware and software installation and configuration, applications use, and trouble-shooting computer use problems.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA056036-05
Application #
6658322
Study Section
Project Start
2002-06-01
Project End
2003-05-31
Budget Start
1998-10-01
Budget End
1999-09-30
Support Year
5
Fiscal Year
2002
Total Cost
$279,549
Indirect Cost
Name
Thomas Jefferson University
Department
Type
DUNS #
061197161
City
Philadelphia
State
PA
Country
United States
Zip Code
19107
Sullivan-Reed, Katherine; Bolton-Gillespie, Elisabeth; Dasgupta, Yashodhara et al. (2018) Simultaneous Targeting of PARP1 and RAD52 Triggers Dual Synthetic Lethality in BRCA-Deficient Tumor Cells. Cell Rep 23:3127-3136
Lu, Huimin; Bowler, Nicholas; Harshyne, Larry A et al. (2018) Exosomal ?v?6 integrin is required for monocyte M2 polarization in prostate cancer. Matrix Biol 70:20-35
Lapadula, Dominic; Farias, Eduardo; Randolph, Clinita E et al. (2018) Effects of Oncogenic G?q and G?11 Inhibition by FR900359 in Uveal Melanoma. Mol Cancer Res :
Vite, Alexia; Zhang, Caimei; Yi, Roslyn et al. (2018) ?-Catenin-dependent cytoskeletal tension controls Yap activity in the heart. Development 145:
McNair, Christopher; Xu, Kexin; Mandigo, Amy C et al. (2018) Differential impact of RB status on E2F1 reprogramming in human cancer. J Clin Invest 128:341-358
Garcia, Samantha A; Lebrun, Aurore; Kean, Rhonda B et al. (2018) Clearance of attenuated rabies virus from brain tissues is required for long-term protection against CNS challenge with a pathogenic variant. J Neurovirol 24:606-615
Vido, Michael J; Le, Kaitlyn; Hartsough, Edward J et al. (2018) BRAF Splice Variant Resistance to RAF Inhibitor Requires Enhanced MEK Association. Cell Rep 25:1501-1510.e3
Brody, Jonathan R; Dixon, Dan A (2018) Complex HuR function in pancreatic cancer cells. Wiley Interdiscip Rev RNA 9:e1469
Liao, Lili; Liu, Zongzhi Z; Langbein, Lauren et al. (2018) Multiple tumor suppressors regulate a HIF-dependent negative feedback loop via ISGF3 in human clear cell renal cancer. Elife 7:
Heeke, Arielle L; Pishvaian, Michael J; Lynce, Filipa et al. (2018) Prevalence of Homologous Recombination-Related Gene Mutations Across Multiple Cancer Types. JCO Precis Oncol 2018:

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