The Chemical Biology Core (CBC) offers Moffitt Cancer Center (MCC) members access to state-of-the-art technology, instruments, expertise and infrastructure necessary for studying proteins involved in tumorigenesis. The CBC also provides synthetic and medicinal chemistry services for synthesizing chemical probes and to develop lead candidates into compounds that are suitable for pre-clinical cancer efficacy and safety studies.
The specific aims of the CBC are to: 1) assist in study design, implementation of synthesis of chemical probes, X-ray crystallography, and protein production via consultation and collaborations; 2) provide members with resources to study the structure of proteins involved in tumorigenesis; and 3) provide access and training on state-of-the-art instrumentation to members. The CBC is composed of two highly specialized sections, Chemistry and Protein Crystallography, which provide services in Synthetic/Medicinal Chemistry, Protein Crystallography, and Biochemistry. The CBC employs five experienced full-time staff, who provide expertise in chemistry, drug discovery and development, protein production, crystallography and biochemistry, and cancer biology. Chemistry services offered by the CBC include: 1) synthesis of focused libraries for hit-to-lead-optimization of new anti-cancer compounds; 2) synthesis of complex small molecules as chemical probes; 3) medicinal chemistry and scale-up synthesis, to provide pre-clinical compounds for potency, selectivity, efficacy and safety studies; 4) analytical chemistry services, to determine physicochemical properties of potent compounds; 5) and synthesis of tagged chemical probes for affinity-based chemical proteomics studies. The CBC also provides support for cloning, expression, large-scale purification of target proteins, X-ray crystallography, high-resolution structure determination, structure-guided synthesis, protein-protein and protein-ligand/drug interactions, and structure of protein-inhibitor complexes. Facilitating this work, the CBC provides members access to high-end instrumentation and associated training. Over the past five years, chemistry, protein production, and crystallography services have supported the projects of 49 members, including services critical for 14 new research grant awards to members. The CBC contributed to 52 publications via synthesis of compounds, protein production, and high-end instrumentation, and core staff were co-authors on the publications of 24 members. During the most recent fiscal year, the CBC provided service for 23 members in four research programs: CBMM (12 members), CBE (6), IMM (3), and CE (2). Regarding use of the CBC, 81% was by peer-review-funded members. The CBC also provided preliminary data, technical sections, and consultation for 21 research proposals during the most recent year. The CBC is supported by institutional and CCSG funds and will continue to provide outstanding chemical biology and state-of-the-art technologies to MCC members.

National Institute of Health (NIH)
National Cancer Institute (NCI)
Center Core Grants (P30)
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Subcommittee A - Cancer Centers (NCI-A)
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H. Lee Moffitt Cancer Center & Research Institute
Research Institutes
United States
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Hellmann, Matthew D; Callahan, Margaret K; Awad, Mark M et al. (2018) Tumor Mutational Burden and Efficacy of Nivolumab Monotherapy and in Combination with Ipilimumab in Small-Cell Lung Cancer. Cancer Cell 33:853-861.e4
Trabert, Britton; Poole, Elizabeth M; White, Emily et al. (2018) Analgesic Use and Ovarian Cancer Risk: An Analysis in the Ovarian Cancer Cohort Consortium. J Natl Cancer Inst :
Palmer, Amanda M; Brandon, Thomas H (2018) How do electronic cigarettes affect cravings to smoke or vape? Parsing the influences of nicotine and expectancies using the balanced-placebo design. J Consult Clin Psychol 86:486-491
Dougoud-Chauvin, Vérène; Lee, Jae Jin; Santos, Edgardo et al. (2018) Using Big Data in oncology to prospectively impact clinical patient care: A proof of concept study. J Geriatr Oncol 9:665-672
Wu, Xiaowei; Ji, Haitao (2018) Rhodium(iii)-catalyzed C-H allylation of indoles with allyl alcohols via ?-hydroxide elimination. Org Biomol Chem 16:5691-5698
Liu, Ying; Kim, Jongphil; Balagurunathan, Yoganand et al. (2018) Prediction of pathological nodal involvement by CT-based Radiomic features of the primary tumor in patients with clinically node-negative peripheral lung adenocarcinomas. Med Phys 45:2518-2526
Davis, Stacy N; Govindaraju, Swapamthi; Jackson, Brittany et al. (2018) Recruitment Techniques and Strategies in a Community-Based Colorectal Cancer Screening Study of Men and Women of African Ancestry. Nurs Res 67:212-221
Martínez, Úrsula; Brandon, Thomas H; Sutton, Steven K et al. (2018) Associations between the smoking-relatedness of a cancer type, cessation attitudes and beliefs, and future abstinence among recent quitters. Psychooncology 27:2104-2110
Perales-Puchalt, Alfredo; Perez-Sanz, Jairo; Payne, Kyle K et al. (2018) Frontline Science: Microbiota reconstitution restores intestinal integrity after cisplatin therapy. J Leukoc Biol 103:799-805
Nelson, Ashley M; Jim, Heather S L; Small, Brent J et al. (2018) Sleep disruption among cancer patients following autologous hematopoietic cell transplantation. Bone Marrow Transplant 53:307-314

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