) The Cell Cycle Disregulation Program comprises members from a wide variety of disciplines. The program is designed to integrate multidisciplinary studies on cell cycle control with questions concerning preneoplastic initiation, progression, and treatment. The program approaches these questions through a variety of methods which include cell biology, genetics, molecular biology, and biochemistry. Organization of the program is arranged into three major areas: 1) regulated entry into the cell division cycle; 2) the characterization of the molecular components of the cell cycle engine and its control; and 3) the fidelity and disregulation of cell cycle control. The examination of these processes in normal and neoplastic tissues should provide information about key steps in neoplastic transformation and aid in the identification of molecular targets for effective therapy. Comparison of critical processes between tissues and between species may also provide important insights given documented differences in carcinogenic frequency. Many members also belong to organ/site-specific programs within the Cancer Center, which will facilitate a mutual exchange of information with clinical personnel. Interactions will be stimulated through a weekly research seminar series, an annual retreat, and informal discussion groups examining the basis of carcinogenesis.
| Sannino, Sara; Guerriero, Christopher J; Sabnis, Amit J et al. (2018) Compensatory increases of select proteostasis networks after Hsp70 inhibition in cancer cells. J Cell Sci 131: |
| Lam, Christine; Ferguson, Ian D; Mariano, Margarette C et al. (2018) Repurposing tofacitinib as an anti-myeloma therapeutic to reverse growth-promoting effects of the bone marrow microenvironment. Haematologica 103:1218-1228 |
| Truillet, Charles; Parker, Matthew F L; Huynh, Loc T et al. (2018) Measuring glucocorticoid receptor expression in vivo with PET. Oncotarget 9:20399-20408 |
| Phillips, Kathryn A; Trosman, Julia R; Deverka, Patricia A et al. (2018) Insurance coverage for genomic tests. Science 360:278-279 |
| Phillips, Kathryn A (2018) Evolving Payer Coverage Policies on Genomic Sequencing Tests: Beginning of the End or End of the Beginning? JAMA 319:2379-2380 |
| Puri, Sapna; Roy, Nilotpal; Russ, Holger A et al. (2018) Replication confers ? cell immaturity. Nat Commun 9:485 |
| An, Zhenyi; Aksoy, Ozlem; Zheng, Tina et al. (2018) Epidermal growth factor receptor and EGFRvIII in glioblastoma: signaling pathways and targeted therapies. Oncogene 37:1561-1575 |
| Behr, Spencer C; Villanueva-Meyer, Javier E; Li, Yan et al. (2018) Targeting iron metabolism in high-grade glioma with 68Ga-citrate PET/MR. JCI Insight 3: |
| Rubenstein, James L; Geng, Huimin; Fraser, Eleanor J et al. (2018) Phase 1 investigation of lenalidomide/rituximab plus outcomes of lenalidomide maintenance in relapsed CNS lymphoma. Blood Adv 2:1595-1607 |
| An, Zhenyi; Knobbe-Thomsen, Christiane B; Wan, Xiaohua et al. (2018) EGFR Cooperates with EGFRvIII to Recruit Macrophages in Glioblastoma. Cancer Res 78:6785-6794 |
Showing the most recent 10 out of 192 publications
