The In Vivo Therapeutics Core (IVTC) is a state-of-the-art shared resource of the Indiana University Melvin and Bren Simon Cancer Center (IUSCC) that serves as a recognized shared resource of the Indiana University School of Medicine (IUSOM), providing cost-effective and comprehensive services including, but not limited to, on-site breeding facilities as well as a numerous in vivo pharmacology models to facilitate the development and testing of novel pharmacological &cellular therapies. It is a certified shared resource of the Indiana Clinical and Translational Sciences Institute (iCTSI). The IVTC maintains multiple mouse colonies on campus. Additionally, this shared resource offers a range of services that span from traditional xenograft services to advanced humanized mouse models of cancer, and offer the flexibility to customize studies. This includes setting up new models of disease and validating in the core. IVTC personnel are highly trained and have extensive experience in many different animal models, dose routes, and species (including transplantation, surgical, and stereotactic procedures) and equipment. The shared resource has increased in its size and now has four personnel. IVTC supports the research and development of safe and more efficacious drug treatment for IUSCC investigators, and IVTC continues to be engaged with their customers to enable the necessary research capabilities be built and validated in their quest to obtain external funding. The IVTC interacts closely with the Clinical Pharmacology Analytical Core (CPAC) and other IUSCC shared resources including the Chemical Genomics Core, and the Indiana Institute for Biological Imaging Sciences. For example, the drug discovery process should provide a delicate balance between the chemistry, pharmacology, and pharmacokinetics of the drug. Over the past few years, CPAC and IVTC have worked together to generate data that allow PIs to better evaluate molecules being developed within the IUSCC that show promise as novel cancer drugs. The IVTC performs the live phase study {in vivo) and collects samples for CPAC to perform the kinetics. Both of these core leaders are directly involved in study design prior to project initiation.

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
2P30CA082709-15
Application #
8781061
Study Section
Subcommittee G - Education (NCI)
Project Start
1999-09-22
Project End
2019-08-31
Budget Start
2014-09-01
Budget End
2015-08-31
Support Year
15
Fiscal Year
2014
Total Cost
$35,742
Indirect Cost
$15,953
Name
Indiana University-Purdue University at Indianapolis
Department
Type
DUNS #
603007902
City
Indianapolis
State
IN
Country
United States
Zip Code
46202
Olivos 3rd, David J; Perrien, Daniel S; Hooker, Adam et al. (2018) The proto-oncogene function of Mdm2 in bone. J Cell Biochem 119:8830-8840
Shiue, Kevin; Cerra-Franco, Alberto; Shapiro, Ronald et al. (2018) Histology, Tumor Volume, and Radiation Dose Predict Outcomes in NSCLC Patients After Stereotactic Ablative Radiotherapy. J Thorac Oncol 13:1549-1559
Liu, Yunhua; Xu, Hanchen; Van der Jeught, Kevin et al. (2018) Somatic mutation of the cohesin complex subunit confers therapeutic vulnerabilities in cancer. J Clin Invest 128:2951-2965
Pin, Fabrizio; Barreto, Rafael; Kitase, Yukiko et al. (2018) Growth of ovarian cancer xenografts causes loss of muscle and bone mass: a new model for the study of cancer cachexia. J Cachexia Sarcopenia Muscle 9:685-700
Robertson, Michael J; Stamatkin, Christopher W; Pelloso, David et al. (2018) A Dose-escalation Study of Recombinant Human Interleukin-18 in Combination With Ofatumumab After Autologous Peripheral Blood Stem Cell Transplantation for Lymphoma. J Immunother 41:151-157
Huang, Xinxin; Guo, Bin; Liu, Sheng et al. (2018) Neutralizing negative epigenetic regulation by HDAC5 enhances human haematopoietic stem cell homing and engraftment. Nat Commun 9:2741
Serratore, Nina D; Baker, Kortany M; Macadlo, Lauren A et al. (2018) A Novel Sterol-Signaling Pathway Governs Azole Antifungal Drug Resistance and Hypoxic Gene Repression in Saccharomyces cerevisiae. Genetics 208:1037-1055
Hoggatt, Jonathan; Singh, Pratibha; Tate, Tiffany A et al. (2018) Rapid Mobilization Reveals a Highly Engraftable Hematopoietic Stem Cell. Cell 172:191-204.e10
Filley, Anna; Henriquez, Mario; Bhowmik, Tanmoy et al. (2018) Immunologic and gene expression profiles of spontaneous canine oligodendrogliomas. J Neurooncol 137:469-479
Sishtla, Kamakshi; Pitt, Natalie; Shadmand, Mehdi et al. (2018) Observations on spontaneous tumor formation in mice overexpressing mitotic kinesin Kif14. Sci Rep 8:16152

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