Abstract

Central Microscopy Microscopy remains central to both laboratory and clinical cancer research. The principal goal of the Central Microscopy Research Facility (CMRF) is to provide services and instruction to HCCC investigators interested in using microscopy technology for cancer research. The CMRF provides technical assistance for labor intensive techniques and ready access to highly specialized and expensive equipment. It supports cancer research being done by members of all 6 research programs. Specific services available to HCCC investigators include expertise related to tissue preparation, fixation and staining for: 1) Light microscopy 2) Histochemical and fluorescence microscopy 3) Confocal, multiphoton and electron microscopy 4) In situ hybridization 5) Elemental and chemical characterization 5) In vivo small animal imaging using the IVIS imaging system The CMRF provides consultation and assistance to HCCC investigators in the development and application of new and specialized morphological methods relevant to cancer research. In 2009, 80 HCCC members with peer reviewed funding utilized the CMRF.

Public Health Relevance

Light, fluorescence, confocal, and electron microscopy are central tools for many aspects of laboratory and clinical cancer research. The CMRF provides a comprehensive, state-of-the-art array of microscopy instrumentation and techniques to HCCC members conducting cancer research.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Cancer Institute (NCI)
Type
Center Core Grants (P30)
Project #
5P30CA086862-13
Application #
8466221
Study Section
Subcommittee G - Education (NCI)
Project Start
Project End
Budget Start
2013-04-01
Budget End
2014-03-31
Support Year
13
Fiscal Year
2013
Total Cost
$82,596
Indirect Cost
$31,206

  Institution

Name
University of Iowa
Department
Type
DUNS #
062761671
City
Iowa City
State
IA
Country
United States
Zip Code
52242

  Publications

Zhang, Xuchen; Patil, Deepa; Odze, Robert D et al. (2018) The microscopic anatomy of the esophagus including the individual layers, specialized tissues, and unique components and their responses to injury. Ann N Y Acad Sci :
Schaal, Justin B; Maretzky, Thorsten; Tran, Dat Q et al. (2018) Macrocyclic ?-defensins suppress tumor necrosis factor-? (TNF-?) shedding by inhibition of TNF-?-converting enzyme. J Biol Chem 293:2725-2734
Tanos, Barbara E; Yeaman, Charles; Rodriguez-Boulan, Enrique (2018) An emerging role for IQGAP1 in tight junction control. Small GTPases 9:375-383
Coghill, Anna E; Bellizzi, Andrew M; Lynch, Charles F et al. (2018) Pathology characterization and detection of human papillomavirus type 16 in rectal squamous cell carcinomas. Clin Gastroenterol Hepatol :
Robinett, Zachary N; Bathla, Girish; Wu, Angela et al. (2018) Persistent Oxidative Stress in Vestibular Schwannomas After Stereotactic Radiation Therapy. Otol Neurotol 39:1184-1190
Subramanyam, Shyamal; Kinz-Thompson, Colin D; Gonzalez Jr, Ruben L et al. (2018) Observation and Analysis of RAD51 Nucleation Dynamics at Single-Monomer Resolution. Methods Enzymol 600:201-232
Borcherding, Nicholas; Cole, Kimberly; Kluz, Paige et al. (2018) Re-Evaluating E-Cadherin and ?-Catenin: A Pan-Cancer Proteomic Approach with an Emphasis on Breast Cancer. Am J Pathol 188:1910-1920
Mansour, John C; Chavin, Kenneth; Morris-Stiff, Gareth et al. (2018) Management of asymptomatic, well-differentiated PNETs: results of the Delphi consensus process of the Americas Hepato-Pancreato-Biliary Association. HPB (Oxford) :
Scherer, Laura D; Kullgren, Jeffrey T; Caverly, Tanner et al. (2018) Medical Maximizing-Minimizing Preferences Predict Responses to Information about Prostate-Specific Antigen Screening. Med Decis Making 38:708-718
Gupta, Sarika; Karandikar, Nitin J; Ginader, Timothy et al. (2018) Flow cytometric aberrancies in plasma cell myeloma and MGUS - correlation with laboratory parameters. Cytometry B Clin Cytom 94:500-508

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