The Oregon Hearing Core Center (OHCC) will support seven principal investigators, funded by the NIDCD and other institutes, with a strong focus and a substantial record of accomplishments in the auditory and vestibular sciences. The goal of the OHCC is to centralize expertise on bioengineering, imaging, and mouse genetics in order to enhance presently funded research projects, including stimulating collaborations between participating investigators. In order to achieve these goals, three Core facilities are proposed. Core 1 (Bioengineering; Alfred Nuttall, director) will provide computer hardware and software support, as well as expertise and instrumentation for measurement of hearing acuity in live animals. Core 2 (Imaging; Dennis Trune and Peter Steyger, co-directors) will centralize confocal and electron-microscopic imaging through the existing OHRC infrastructure. Core 3 (Mouse Molecular Genetics; Peter Gillespie, director) will provide expertise on mouse husbandry and genotyping, as well as providing services for assembly of transgenic and gene-targeting constructs. By providing services not available through existing grants, this core facility will enhance research carried out by core-facility users and stimulate productive collaborations.

National Institute of Health (NIH)
National Institute on Deafness and Other Communication Disorders (NIDCD)
Center Core Grants (P30)
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Special Emphasis Panel (ZDC1-SRB-A (38))
Program Officer
Donahue, Amy
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Oregon Health and Science University
Schools of Medicine
United States
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Wang, Lingyan; Kempton, J Beth; Brigande, John V (2018) Gene Therapy in Mouse Models of Deafness and Balance Dysfunction. Front Mol Neurosci 11:300
Oh, Yonghee; Reiss, Lina A J (2018) Binaural Pitch Fusion: Effects of Amplitude Modulation. Trends Hear 22:2331216518788972
Kachelmeier, Allan; Shola, Tsering; Meier, William B et al. (2018) Simplified, automated methods for assessing pixel intensities of fluorescently-tagged drugs in cells. PLoS One 13:e0206628
Krey, Jocelyn F; Dumont, Rachel A; Wilmarth, Philip A et al. (2018) ELMOD1 Stimulates ARF6-GTP Hydrolysis to Stabilize Apical Structures in Developing Vestibular Hair Cells. J Neurosci 38:843-857
Reiss, Lina A J; Fowler, Jennifer R; Hartling, Curtis L et al. (2018) Binaural Pitch Fusion in Bilateral Cochlear Implant Users. Ear Hear 39:390-397
Oh, Yonghee; Reiss, Lina A J (2017) Binaural pitch fusion: Pitch averaging and dominance in hearing-impaired listeners with broad fusion. J Acoust Soc Am 142:780
Zhang, Jinhui; Chen, Songlin; Cai, Jing et al. (2017) Culture media-based selection of endothelial cells, pericytes, and perivascular-resident macrophage-like melanocytes from the young mouse vestibular system. Hear Res 345:10-22
Sheets, Lavinia; He, Xinyi J; Olt, Jennifer et al. (2017) Enlargement of Ribbons in Zebrafish Hair Cells Increases Calcium Currents But Disrupts Afferent Spontaneous Activity and Timing of Stimulus Onset. J Neurosci 37:6299-6313
Reiss, Lina A J; Shayman, Corey S; Walker, Emily P et al. (2017) Binaural pitch fusion: Comparison of normal-hearing and hearing-impaired listeners. J Acoust Soc Am 141:1909
Erickson, Timothy; Morgan, Clive P; Olt, Jennifer et al. (2017) Integration of Tmc1/2 into the mechanotransduction complex in zebrafish hair cells is regulated by Transmembrane O-methyltransferase (Tomt). Elife 6:

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